Inhibitory gain modulation of defense behaviors by zona incerta.
Inhibitory gain modulation of defense behaviors by zona incerta.
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DOI：
10.1038/s41467-018-03581-6
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发表时间：
2018-03-20
影响因子：
16.6
通讯作者：
Tao HW
中科院分区：
文献类型：
--
作者：
Chou XL;Wang X;Zhang ZG;Shen L;Zingg B;Huang J;Zhong W;Mesik L;Zhang LI;Tao HW
不确定带(Zi)是一种功能神秘的丘脑底核，内含大部分抑制性神经元。在这里，我们发现ZI(ZIR)吻侧区的GABA能神经元直接支配中脑导水管周围灰质(PAG)背外侧和腹外侧室的兴奋性神经元，而不是抑制性神经元，这两个神经元分别驱动飞行和冻结行为。光基因激活ZIR神经元或其向PAG的投射减少了声音诱导的先天飞行反应和条件性冻结反应，而这些神经元的光基因抑制可能通过增益调制机制增强了这些防御行为。在条件性冰冻反应消退过程中，ZIR活性逐渐增加，抑制ZIR活性会削弱恐惧消退的表达。此外，ZIR由内侧前额叶皮质(MPFC)支配，沉默mPFC可阻止消退时ZIR活性的增加和恐惧消退的表达。综上所述，我们的结果表明ZIR参与了防御行为的调节。不确定带(Zi)是一种抑制性丘脑底核，具有多种连接性，但其功能重要性尚未得到广泛研究。作者报道，ZI接受mPFC输入，并通过其向PAG的抑制性投射调节先天和后天防御行为。
Zona incerta (ZI) is a functionally mysterious subthalamic nucleus containing mostly inhibitory neurons. Here, we discover that GABAergic neurons in the rostral sector of ZI (ZIr) directly innervate excitatory but not inhibitory neurons in the dorsolateral and ventrolateral compartments of periaqueductal gray (PAG), which can drive flight and freezing behaviors respectively. Optogenetic activation of ZIr neurons or their projections to PAG reduces both sound-induced innate flight response and conditioned freezing response, while optogenetic suppression of these neurons enhances these defensive behaviors, likely through a mechanism of gain modulation. ZIr activity progressively increases during extinction of conditioned freezing response, and suppressing ZIr activity impairs the expression of fear extinction. Furthermore, ZIr is innervated by the medial prefrontal cortex (mPFC), and silencing mPFC prevents the increase of ZIr activity during extinction and the expression of fear extinction. Together, our results suggest that ZIr is engaged in modulating defense behaviors. Zona incerta (ZI) is an inhibitory subthalamic nucleus with diverse connectivity yet its functional importance has not been extensively studied. Here the authors report that ZI receives mPFC input and can modulate both innate and learned defensive behaviors via its inhibitory projection to the PAG.
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影响因子：
1.1
作者：
Khan, Sadaquate;Mooney, Lucy;Gill, Steven S.
通讯作者：
Gill, Steven S.
影响因子：
25
作者：
Boyden, ES;Zhang, F;Deisseroth, K
通讯作者：
Deisseroth, K
DOI：
10.1126/science.aac6472
发表时间：
2015-10-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chen J;Kriegstein AR
通讯作者：
Kriegstein AR
影响因子：
16.2
作者：
Liang F;Xiong XR;Zingg B;Ji XY;Zhang LI;Tao HW
通讯作者：
Tao HW
影响因子：
2
作者：
Laurent, Vincent;Westbrook, R. Frederick
通讯作者：
Westbrook, R. Frederick