Temporally and functionally distinct large-scale brain network dynamics supporting task switching.
Temporally and functionally distinct large-scale brain network dynamics supporting task switching.
复制标题
支持任务转换的时间和功能不同的大规模脑网络动力学。
DOI：
10.1016/j.neuroimage.2022.119126
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发表时间：
2022-07-01
期刊：
影响因子：
5.7
通讯作者：
Asano E
中科院分区：
文献类型：
--
作者：
Mitsuhashi T;Sonoda M;Firestone E;Sakakura K;Jeong JW;Luat AF;Sood S;Asano E
我们的日常活动需要在毫秒级的竞争反应之间频繁切换。我们确定了在任务转换过程中快速、大规模脑网络动力学的时空特征和功能意义。这项横断面研究调查了在颅内脑电(IEEG)记录期间玩Lumity认知灵活性训练游戏的耐药灶性癫痫患者。根据给定的任务规则，不可预测地在试验之间切换，参与者必须向刺激指向或移动的方向滑动屏幕。利用这些数据，我们描述了iEEG高伽马增强在切换试验期间比重复试验中发生得更强烈的时空特征，与任务规则(指向或移动)、刺激内一致性(刺激指向和移动的方向在给定试验中相同或不同)或紧邻前一反应的准确性的影响无关。扩散加权成像(DWI)脑束成像确定了在任务转换试验中表现出增强激活的远端皮质区域是否与白质束直接相连。一次又一次的iEEG分析推断，与任务切换相关的高伽马增强的强度是否通过练习发生了变化，以及高伽马幅度是否预测了切换试验中即将到来的反应的准确性。在五分钟的游戏过程中，每个患者平均完成了221.4次试验(范围为171-285次)。任务切换试验增加了反应时间，而后来的试验减少了反应时间。对来自860个脑区的iEEG信号的分析有效地阐明了任务切换、任务规则和错误后特定的高伽马调制的明显时空特征。提示后，任务转换相关的高伽马增强在260ms后在右侧距骨皮质启动，330ms后在右侧楔前叶启动，420ms后在右侧内嗅区启动，450ms后在双侧前中额回启动。弥散加权成像成功地显示了连接右侧视觉区域与楔前和额中额前区域的直接白质束的存在，但没有显示右侧楔前和额中前区域之间的直接白质束。在后来的试验中，任务相关的高伽马幅度在距骨、内嗅觉和额中前部减少，但在楔前增加。在功能上，增强的线索后楔前高伽马增强提高了Switch试验中后续反应的准确性。我们的多模式分析揭示了支持任务切换的两个时间和功能上不同的网络动态。视觉-楔前叶通路中的高伽马增强可能反映了促进注意力转移到给定的更新的任务规则的神经过程。视觉-背外侧前额叶通路中的高伽马活动通过练习迅速减少，可能反映了执行适当的刺激-反应转换的成本。
Our daily activities require frequent switches among competing responses at the millisecond time scale. We determined the spatiotemporal characteristics and functional significance of rapid, large-scale brain network dynamics during task switching. This cross-sectional study investigated patients with drug-resistant focal epilepsy who played a Lumosity cognitive flexibility training game during intracranial electroencephalography (iEEG) recording. According to a given task rule, unpredictably switching across trials, participants had to swipe the screen in the direction the stimulus was pointing or moving. Using this data, we described the spatiotemporal characteristics of iEEG high-gamma augmentation occurring more intensely during switch than repeat trials, unattributable to the effect of task rule (pointing or moving), within-stimulus congruence (the direction of stimulus pointing and moving was same or different in a given trial), or accuracy of an immediately preceding response. Diffusion-weighted imaging (DWI) tractography determined whether distant cortical regions showing enhanced activation during task switch trials were directly connected by white matter tracts. Trial-by-trial iEEG analysis deduced whether the intensity of task switch-related high-gamma augmentation was altered through practice and whether high-gamma amplitude predicted the accuracy of an upcoming response among switch trials. The average number of completed trials during five-minute gameplay was 221.4 per patient (range: 171–285). Task switch trials increased the response times, whereas later trials reduced them. Analysis of iEEG signals sampled from 860 brain sites effectively elucidated the distinct spatiotemporal characteristics of task switch, task rule, and post-error-specific high-gamma modulations. Post-cue, task switch-related high-gamma augmentation was initiated in the right calcarine cortex after 260 ms, right precuneus after 330 ms, right entorhinal after 420 ms, and bilateral anterior middle-frontal gyri after 450 ms. DWI tractography successfully showed the presence of direct white matter tracts connecting the right visual areas to the precuneus and anterior middle-frontal regions but not between the right precuneus and anterior middle-frontal regions. Task-related high-gamma amplitudes in later trials were reduced in the calcarine, entorhinal and anterior middle-frontal regions, but increased in the precuneus. Functionally, enhanced post-cue precuneus high-gamma augmentation improved the accuracy of subsequent responses among switch trials. Our multimodal analysis uncovered two temporally and functionally distinct network dynamics supporting task switching. High-gamma augmentation in the visual-precuneus pathway may reflect the neural process facilitating an attentional shift to a given updated task rule. High-gamma activity in the visual-dorsolateral prefrontal pathway, rapidly reduced through practice, may reflect the cost of executing appropriate stimulus-response translation.
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