Selection-driven trait loss in independently evolved cavefish populations.
Selection-driven trait loss in independently evolved cavefish populations.
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DOI：
10.1038/s41467-023-37909-8
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发表时间：
2023-05-03
影响因子：
16.6
通讯作者：
McGaugh, Suzanne E.
中科院分区：
文献类型：
--
作者：
Moran, Rachel L.;Richards, Emilie J.;Ornelas-Garcia, Claudia Patricia;Gross, Joshua B.;Donny, Alexandra;Wiese, Jonathan;Keene, Alex C.;Kowalko, Johanna E.;Rohner, Nicolas;McGaugh, Suzanne E.
实验室研究表明，一种表型可以由许多不同的基因类型产生；然而，在自然系统中，经常发现表型趋同是由于平行的遗传变化。这表明约束和决定论在进化中发挥了重要作用，并表明某些突变更有可能对表型进化做出贡献。在这里，我们使用全基因组重测序的方法，研究了选择如何在独立的洞穴鱼类谱系中塑造了特征丢失和增强的重复进化。我们表明，对现有遗传变异和从头突变的选择都有助于重复适应。我们的发现为具有较大突变靶点的基因更有可能成为重复进化的底物的假设提供了经验支持，并表明洞穴环境的特征可能影响突变发生的速度。反复进化为适应提供了有价值的见解。在这项研究中，作者发现，鱼类(Astianax Micianus)洞穴适应表型的重复进化是由现有遗传变异的选择驱动的，新的突变和重复选择下的基因比基因组的其余部分更长。
Laboratory studies have demonstrated that a single phenotype can be produced by many different genotypes; however, in natural systems, it is frequently found that phenotypic convergence is due to parallel genetic changes. This suggests a substantial role for constraint and determinism in evolution and indicates that certain mutations are more likely to contribute to phenotypic evolution. Here we use whole genome resequencing in the Mexican tetra, Astyanax mexicanus, to investigate how selection has shaped the repeated evolution of both trait loss and enhancement across independent cavefish lineages. We show that selection on standing genetic variation and de novo mutations both contribute substantially to repeated adaptation. Our findings provide empirical support for the hypothesis that genes with larger mutational targets are more likely to be the substrate of repeated evolution and indicate that features of the cave environment may impact the rate at which mutations occur. Repeated evolution provides valuable insight into adaptation. In this study, the authors found that repeated evolution of cave-adapted phenotypes of a fish (Astyanax mexicanus) was driven by selection on standing genetic variation and novel mutations and genes repeatedly under selection are longer compared to the rest of the genome.
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影响因子：
14.9
作者：
Gene Ontology Consortium
通讯作者：
Gene Ontology Consortium
影响因子：
4.6
作者：
Bilandžija H;Laslo M;Porter ML;Fong DW
通讯作者：
Fong DW
影响因子：
3.4
作者：
Bradic M;Beerli P;García-de León FJ;Esquivel-Bobadilla S;Borowsky RL
通讯作者：
Borowsky RL
DOI：
10.1098/rspb.2018.0243
发表时间：
2018-05-16
影响因子：
4.7
作者：
Bilandzija, Helena;Abraham, Lindsey;Jeffery, William R.
通讯作者：
Jeffery, William R.
影响因子：
3.7
作者：
Bilandžija H;Ma L;Parkhurst A;Jeffery WR
通讯作者：
Jeffery WR