Simultaneous field and R2 mapping to quantify liver iron content using autoregressive moving average modeling.
Simultaneous field and R2 mapping to quantify liver iron content using autoregressive moving average modeling.
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DOI：
10.1002/jmri.23545
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发表时间：
2012-05
影响因子：
4.4
通讯作者：
Hillenbrand, Claudia M.
中科院分区：
文献类型：
--
作者：
Taylor, Brian A.;Loeffler, Ralf B.;Song, Ruitian;McCarville, M. Beth;Hankins, Jane S.;Hillenbrand, Claudia M.
关键词：
研究使用复杂多梯度回波（mGRE）采集和自回归移动平均（ARMA）模型进行同时易感性和R2*测量，以评估铁超载患者的肝铁含量（LIC）。使用ARMA模型处理50个具有幅度和相位mGRE图像的MR检查，该模型提供脂肪分离场图，R2*图和T1-W成像。通过测量肝脏和右横腹肌之间的敏感性，计算出LIC。利用线性最小二乘回归分析确定了敏感性测量所得LIC与R2*测量所得LIC之间的关系。由R2*测得的LIC与敏感性法测得的LIC高度相关（mg/g dry = 8.99±0.15 × （mg Fe/ml湿肝）- 2.38±0.29,R2=0.94）。肝内场不均匀性与R2*相关（R2=0.85）。通过在复杂的mGRE图像上使用ARMA模型，可以同时进行磁化率和基于R2*的LIC测量。磁化率测量可以用来帮助验证R2*测量在铁过载的评估。
To investigate the use of a complex multi-gradient echo (mGRE) acquisition and an autoregressive moving average (ARMA) model for simultaneous susceptibility and R2* measurements for the assessment of liver iron content (LIC) in patients with iron overload. Fifty MR exams with magnitude and phase mGRE images are processed using the ARMA model which provides fat-separated field maps, R2* maps, and T1-W imaging. The LIC is calculated by measuring the susceptibility between the liver and the right transverse abdominal muscle from the field maps. The relationship between LIC derived from susceptibility measurements and LIC from R2* measurements is determined using linear least squares regression analysis. LIC measured from R2* is highly correlated to the LIC from the susceptibility method (mg/g dry = 8.99 ± 0.15 × (mg Fe/ml of wet liver) −2.38 ± 0.29, R2=0.94). The field inhomogeneity in the liver is correlated with R2* (R2=0.85). By using the ARMA model on complex mGRE images, both susceptibility and R2*-based LIC measurements can be made simultaneously. The susceptibility measurement can be used to help verify R2* measurements in the assessment of iron overload.
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影响因子：
3.3
作者：
Kanayama, S;Kuhara, S;Satoh, K
通讯作者：
Satoh, K
DOI：
10.1196/annals.1345.043
发表时间：
2005-01-01
期刊：
COOLEY'S ANEMIA EIGHTH SYMPOSIUM
影响因子：
--
作者：
Fischer, R;Piga, A;Nielsen, P
通讯作者：
Nielsen, P
DOI：
10.1056/nejmct1004810
发表时间：
2011-01-13
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brittenham GM
通讯作者：
Brittenham GM
影响因子：
3.5
作者：
Butensky, E;Fischer, R;Harmatz, P
通讯作者：
Harmatz, P
影响因子：
39.3
作者：
Anderson, LJ;Holden, S;Pennell, DJ
通讯作者：
Pennell, DJ