Visible light. Part II: Photoprotection against visible and ultraviolet light.

Visible light. Part II: Photoprotection against visible and ultraviolet light.
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DOI:
10.1016/j.jaad.2020.11.074
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发表时间:
2021-05
影响因子:
13.8
通讯作者:
Lim HW
Lim HW
中科院分区:
医学1区
文献类型:
--
作者:
Geisler AN;Austin E;Nguyen J;Hamzavi I;Jagdeo J;Lim HW

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皮肤光生物学研究主要集中在太阳光谱的紫外线部分。然而,VL占到达地球表面的EMR的50%,正如本CME第一部分所讨论的那样,VL具有皮肤生物效应,如色素变暗和红斑。对VL的光防护包括躲避阳光,寻找阴凉处,以及使用光防护服。防晒霜中使用的有机和无机紫外线过滤器不能预防VL;只有有色防晒霜才能。在美国,这些过滤器作为非处方药受到FDA的监管,并受到比欧洲、亚洲和澳大利亚更严格的监管。目前还没有关于VL光防护的既定指南。提供VL光保护的替代措施正在探索中。这些新方法包括外用、口服和皮下给药。进一步的开发应侧重于在UVA1(340-400 nm)和VL范围内提供更好的防护,同时增强最终产品的美观性。
Cutaneous photobiology studies have focused primarily on the UV portion of the solar spectrum. However, VL comprises 50% of EMR that reaches the earth’s surface, and, as discussed in Part I of this CME, VL has cutaneous biologic effects such as pigment darkening and erythema. Photoprotection against VL includes sun avoidance, seeking shade, and the use of photoprotective clothing. Organic and inorganic UV filters used in sunscreens do not protect against VL; only tinted sunscreens do. In the US, these filters are regulated by the FDA as an over-the-counter drug and are subjected to more stringent regulations than in Europe, Asia, and Australia. There are no established guidelines regarding VL photoprotection. Alternative measures to confer VL photoprotection are being explored. These novel methods include topical, oral, and subcutaneous agents. Further development should focus on better protection in the range of UVA1 (340–400nm) and VL while enhancing the cosmesis of the final products.
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