Placental MAOA expression mediates prenatal stress effects on temperament in 12-month-olds.
Placental MAOA expression mediates prenatal stress effects on temperament in 12-month-olds.
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胎盘 MAOA 表达介导产前应激对 12 个月大婴儿气质的影响。
DOI：
10.1002/icd.2094
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发表时间：
2018
影响因子：
2.2
通讯作者：
Nomura,Yoko
中科院分区：
文献类型：
--
作者：
Pehme,PatriciaM;Zhang,Wei;Finik,Jackie;Pritchett,Alexandra;Buthmann,Jessica;Dana,Kathryn;Hao,Ke;Nomura,Yoko
胎盘适应母体环境，其变化可能对儿童的气质发育产生持久的影响。产前压力与胎盘中单胺氧化酶a （MAOA）基因表达的下调和气质困难有关。利用一项正在进行的纵向研究，我们分析了95对母子的数据，以调查MAOA是否介导产前压力和婴儿气质之间的关联。产前压力被定义为在怀孕期间暴露于超级风暴桑迪（Sandy）中。通过婴儿行为问卷-修订来测量婴儿气质。定量测定胎盘组织中MAOA基因的表达。微笑和大笑分量表得分与桑迪暴露和MAOA胎盘基因表达独立相关。中介分析证实，MAOA基因表达在Sandy与笑与笑亚量表的关系中起部分中介作用，表明子宫内接触Sandy可能通过下调胎盘MAOA基因表达而导致笑与笑的频率降低。这些影响可能会破坏最佳的气质轨迹，并增加心理问题的风险。胎盘表观遗传标记可以为高危儿童的早期干预提供多维模型。本研究探讨了胎盘MAOA基因表达是否在产前应激和婴儿气质之间起生物学中介作用。中介分析显示产前压力对微笑和大笑分量表有部分中介作用。子宫内应激可以改变MAOA基因的表观遗传表达，从而影响气质发育。这些胎盘基因表达可能成为筛查和干预的有用生物标志物。
The placenta adapts to maternal environment and its alterations may have a lasting impact on child's temperament development. Prenatal stress has been linked to both a downregulation of monoamine oxidase A (MAOA) gene expression in the placenta and to difficult temperament. Capitalizing on an ongoing longitudinal study, we analysed data from 95 mother–child dyads to investigate whether MAOA mediates the association between prenatal stress and infant temperament. Prenatal stress was defined as exposure to Superstorm Sandy (Sandy) during pregnancy. Infant temperament was measured by Infant Behaviour Questionnaire‐Revised. MAOA gene expression was quantified in placenta tissue. The Smiling and Laughter subscale score was independently associated with Sandy exposure and MAOA placental gene expression. Mediation analysis confirmed that MAOA expression partially mediated the relationship between Sandy and Smiling and Laughter subscale, suggesting that in utero exposure to Sandy could induce lower frequency of smiling and laughter via downregulation of placental MAOA gene expression. These effects could compromise optimal temperamental trajectory and contribute to risk for psychological problems. Placental epigenetic markers can contribute to a multidimensional model of early intervention for high‐risk children.HighlightsThe study examined whether placental MAOA gene expression operates as a biological mediator in the relationship between prenatal stress and infant temperament.Mediation analyses revealed a partial mediation between prenatal stress and Smiling and Laughter subscale.Stress in utero could change MAOA gene expression epigenetically, which could shape temperament development. Such placental gene expressions may become useful biomarkers for screening and intervention.
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