Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms.

Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms.
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DOI:
10.3390/vaccines9030263
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发表时间:
2021-03-16
期刊:
影响因子:
7.8
通讯作者:
Long MT
Long MT
中科院分区:
医学3区
文献类型:
--
作者:
Carvalho VL;Long MT

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节肢动物传播的病毒(虫媒病毒)是全球性的病原体,在地方流行,局部爆发,并不断侵入新的地点。针对虫媒病毒的疫苗很少;大多数用于人类的疫苗正在开发或临床试验中。昆虫特异性病毒(ISV)通过创建ISV/虫媒病毒嵌合体为虫媒病毒蛋白的表达提供了独特的平台。研究表明,这些疫苗与野生型疫苗相比具有一些优势,具有良好的效果。在这篇综述中,我们讨论了这些潜在的疫苗使用ISV的现状。
Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are in development or clinical trials. Insect-specific viruses (ISVs) offer a unique platform for expression of arbovirus proteins, through the creation of ISV/arbovirus chimeras. Studies have shown promising results of these vaccines with several advantages over their wild-type counterparts. In this review, we discuss the current status of these potential vaccines using ISVs.
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