Time-Restricted Feeding and Metabolic Outcomes in a Cohort of Italian Adults.
Time-Restricted Feeding and Metabolic Outcomes in a Cohort of Italian Adults.
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DOI：
10.3390/nu13051651
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发表时间：
2021-05-13
期刊：
影响因子：
5.9
通讯作者：
Galvano F
中科院分区：
文献类型：
--
作者：
Currenti W;Buscemi S;Cincione RI;Cernigliaro A;Godos J;Grosso G;Galvano F
背景：目前正在进行的研究探索食物的时间和频率对健康和疾病的影响。虽然有越来越多的科学文献表明间歇性禁食（IF）在实验室环境和动物中的潜在健康益处，但关于IF对人类的研究有限。因此，本研究的目的是评估成年个体的进食/禁食时间窗与代谢结果之间的关系。方法：对生活在意大利南部的1936名成年受试者的饮食和人口统计学数据进行了检查。食物频率问卷（FFQ）进行管理，以确定一个典型的一天的第一餐和最后一餐之间的时间段。然后将受试者分为喂食时间窗持续超过10 h、8 h内（TRF-8）和10 h内的受试者。结果如下：调整与饮食习惯相关的潜在混杂因素后（例如坚持地中海饮食、吃早餐/晚餐），TRF-10与超重/肥胖呈负相关（OR = 0.05，95%CI：0.01，0.07），高血压（OR = 0.24，95% CI：0.13，0.45），血脂异常（OR = 0.26，95% CI：0.10，0.63），而TRF-8仅与超重/肥胖（OR = 0.08，95% CI：0.04，0.15）和高血压（OR = 0.33，95% CI：0.17，0.60）有关。未发现与2型糖尿病相关。结论：进食时间窗受限的个体不太可能超重、肥胖和高血压。需要进一步的研究来明确验证本研究的结果。
Background: research exploring the effects of food timing and frequency on health and disease is currently ongoing. While there is an increasing body of scientific literature showing the potential health benefits of intermittent fasting (IF) in laboratory settings and in animals, studies regarding IF on humans are limited. Therefore, the objective of this research was to evaluate the relationship between the feeding/fasting time window and metabolic outcomes among adult individuals. Methods: dietary and demographic data of 1936 adult subjects living in the south of Italy were examined. Food frequency questionnaires (FFQ) were administered to determine the period of time between the first and the last meal of a typical day. Subjects were then divided into those with a time feeding window lasting more than 10 h, within 8 h (TRF-8) and within 10 h. Results: after adjustment for potential confounding factors related to eating habits (such as adherence to the Mediterranean diet, having breakfast/dinner), TRF-10 was inversely associated with being overweight/obese (OR = 0.05, 95% CI: 0.01, 0.07), hypertension (OR = 0.24, 95% CI: 0.13, 0.45), and dyslipidemias (OR = 0.26, 95% CI: 0.10, 0.63), while TRF-8 only with being overweight/obese (OR = 0.08, 95% CI: 0.04, 0.15) and hypertension (OR = 0.33, 95% CI: 0.17, 0.60). No associations were found with type-2 diabetes. Conclusions: individuals with a restricted feeding time window were less likely to be overweight, obese and hypertensive. Further studies are needed to clearly validate the results of the present study.
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影响因子：
29
作者：
Hatori M;Vollmers C;Zarrinpar A;DiTacchio L;Bushong EA;Gill S;Leblanc M;Chaix A;Joens M;Fitzpatrick JA;Ellisman MH;Panda S
通讯作者：
Panda S
影响因子：
4.2
作者：
Kahleova, Hana;Lloren, Jan Irene;Fraser, Gary E.
通讯作者：
Fraser, Gary E.
昼夜节律的代谢和能量学的融合。
DOI：
10.1126/science.1195027
发表时间：
2010-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bass J;Takahashi JS
通讯作者：
Takahashi JS
影响因子：
20.1
作者：
Gatica D;Chiong M;Lavandero S;Klionsky DJ
通讯作者：
Klionsky DJ
影响因子：
39
作者：
Lowe, Dylan A.;Wu, Nancy;Weiss, Ethan J.
通讯作者：
Weiss, Ethan J.