The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups.
The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups.
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DOI：
10.1093/cercor/bhw330
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Fitzgerald M
中科院分区：
文献类型：
--
作者：
Chang P;Fabrizi L;Olhede S;Fitzgerald M
皮层对伤害性刺激的感知是疼痛体验的一个重要组成部分，但在大脑发育过程中皮层伤害性活动是如何出现的尚不清楚。在这里，我们使用连续遥测皮层电图（ECoG）记录从初级躯体感觉皮层（S1）清醒活跃的幼鼠映射功能性伤害性处理在发育中的大脑在第一个4周的生活。横截面和纵向记录显示，基线S1 ECoG能量随着年龄的增长而稳步增加，在第3周，独特的β分量被独特的θ分量所取代。事件相关电位诱发短暂的伤害性后爪皮肤刺激在所有年龄测试，确认存在的功能性伤害性脊髓丘脑输入S1。然而，后爪切口，这增加了所有年龄的疼痛敏感性，并没有增加S1皮层脑电图能量，直到第3周。在第3周存在皮肤切口的情况下，伽马（20-50 Hz）能量显著增加，同时在第4周时θ（4-8 Hz）能量持续时间更长。连续ECoG记录表明特定的出生后功能阶段的成熟S1皮层伤害性感受。在2 - 4周龄的清醒幼鼠中，持续疼痛“状态”的体感皮层编码变得明显。
Cortical perception of noxious stimulation is an essential component of pain experience but it is not known how cortical nociceptive activity emerges during brain development. Here we use continuous telemetric electrocorticogram (ECoG) recording from the primary somatosensory cortex (S1) of awake active rat pups to map functional nociceptive processing in the developing brain over the first 4 weeks of life. Cross-sectional and longitudinal recordings show that baseline S1 ECoG energy increases steadily with age, with a distinctive beta component replaced by a distinctive theta component in week 3. Event-related potentials were evoked by brief noxious hindpaw skin stimulation at all ages tested, confirming the presence of functional nociceptive spinothalamic inputs in S1. However, hindpaw incision, which increases pain sensitivity at all ages, did not increase S1 ECoG energy until week 3. A significant increase in gamma (20–50 Hz) energy occurred in the presence of skin incision at week 3 accompanied by a longer-lasting increase in theta (4–8 Hz) energy at week 4. Continuous ECoG recording demonstrates specific postnatal functional stages in the maturation of S1 cortical nociception. Somatosensory cortical coding of an ongoing pain “state” in awake rat pups becomes apparent between 2 and 4 weeks of age.
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影响因子：
10.6
作者：
Cirelli C;Tononi G
通讯作者：
Tononi G
影响因子：
5.3
作者：
Colonnese, Matthew T.;Khazipov, Rustem
通讯作者：
Khazipov, Rustem
影响因子：
3
作者：
Chang, Pishan;Hashemi, Kevan S.;Walker, Matthew C.
通讯作者：
Walker, Matthew C.
影响因子：
9.2
作者：
Fabrizi, Lorenzo;Slater, Rebeccah;Worley, Alan;Meek, Judith;Boyd, Stewart;Olhede, Sofia;Fitzgerald, Maria
通讯作者：
Fitzgerald, Maria
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y