Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing.
Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing.
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淋巴细胞通过高内皮微静脉（HEVs）从血液中募集。我们进行了转录组学分析，并确定了区分HEV和毛细血管内皮细胞的分子特征，并定义了组织特异性HEV的专业化。Captain展示了血管发育的基因程序。HEV富含免疫防御和淋巴细胞迁移的基因。我们确定毛细血管和戊型肝炎病毒的标志物和候选机制调节淋巴细胞的招聘，包括淋巴结戊型肝炎病毒选择性跨膜粘蛋白;转录控制功能专门的碳水化合物配体淋巴细胞L-选择素;戊型肝炎病毒表达的分子跨内皮迁移;和淋巴细胞的运动性和趋化性的脂质介质的代谢程序。我们还阐明了碳水化合物识别途径，目标B细胞肠淋巴组织，定义CD 22作为凝集素归巢受体粘膜HEV。
Lymphocytes are recruited from blood by high-endothelial venules (HEVs). We performed transcriptomic analyses and identified molecular signatures that distinguish HEVs from capillary endothelium and that define tissue-specific HEV specialization. Capillaries displayed gene programs for vascular development. HEVs were enriched in genes for immune defense and lymphocyte migration. We identify capillary and HEV markers and candidate mechanisms for regulated lymphocyte recruitment including a lymph node HEV-selective transmembrane mucin; transcriptional control of functionally specialized carbohydrate ligands for lymphocyte L-selectin; HEV expression of molecules for transendothelial migration; and metabolic programs for lipid mediators of lymphocyte motility and chemotaxis. We also elucidate a carbohydrate recognition pathway that targets B cells to intestinal lymphoid tissues, defining CD22 as a lectin-homing receptor for mucosal HEVs.
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影响因子：
56.9
作者：
Butcher, EC;Picker, LJ
通讯作者：
Picker, LJ
影响因子：
56.9
作者：
Campbell, JJ;Hedrick, J;Butcher, EC
通讯作者：
Butcher, EC
影响因子：
20.1
作者：
Bruetsch, Rene;Liebler, Sven S.;Fischer, Andreas
通讯作者：
Fischer, Andreas
影响因子：
20.3
作者：
Doyle, Emily L.;Ridger, Victoria;Cutler, Daniel F.
通讯作者：
Cutler, Daniel F.
影响因子：
3.6
作者：
Kruse, A;Hallmann, R;Butcher, EC
通讯作者：
Butcher, EC