Comorbidity and continuity of depression and conduct problems from elementary school to adolescence.
Comorbidity and continuity of depression and conduct problems from elementary school to adolescence.
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DOI：
10.1037/abn0000339
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发表时间：
2018-04
影响因子：
4.6
通讯作者：
Beauchaine TP
中科院分区：
文献类型：
--
作者：
McDonough-Caplan H;Klein DN;Beauchaine TP
尽管没有重叠的标准集，但品行障碍和抑郁症同时发生的几率比预期的要高得多。当代基于模型的解释异型共病的方法使用因子分析及其变异来评估基于大量人群和双胞胎样本的症状之间的相互关系。这些分析总是得出宽带内部化和外部化的因素，这些因素是更高阶的一般责任因素——这些发现在年龄和信息来源上都是稳健的。虽然基于模型的方法阐明了共病的结构方面，但它们是可变中心的，通常是横断面的。因此，大多数人没有评估共病的发展连续性，或者是否非共病个体未来易患异型共病。我们使用加速纵向设计来评估8-15岁儿童中父母报告的行为问题（CPs）和抑郁症的增长情况，这些儿童在研究开始时被招募到基于症状水平的抑郁组（n=27）、CPs组（n=28）、共病组（n=81）和对照组（n=70）。与这个年龄段的正常发展趋势一致，所有群体都表现出抑郁症的急剧增长，包括那些在研究开始时仅报告CPs的群体。相比之下，CPs的增长仅限于那些在摄入时报告有高症状的人（伴有或不伴有抑郁症），而在只有抑郁症和对照组的参与者中，CPs的增长较低且稳定。据我们所知，这是第一项研究，通过仔细确定的“纯”和共病组，自然随访，证明纯CPs患者可能发生共病性抑郁症，但纯抑郁症患者不太可能发生共病性CPs。
Despite non-overlapping criterion sets, conduct disorder and depression co-occur at much higher rates than expected by chance. Contemporary model-based approaches to explaining heterotypic comorbidity use factor analysis and its variants to evaluate inter-relations among symptoms in large population-based and twin samples. These analyses invariably yield broadband internalizing and externalizing factors, which load on a higher-order general liability factor—findings that are robust across age and informant. Although model-based approaches elucidate structural aspects of comorbidity, they are variable-centered, and usually cross-sectional. Most therefore do not assess developmental continuity of comorbidity, or whether non-comorbid individuals are prospectively vulnerable to heterotypic comorbidity. We use an accelerated longitudinal design to evaluate growth in parent-reported conduct problems (CPs) and depression among children, ages 8–15 years, who were recruited at study entry into depressed only (n=27), CPs only (n=28), comorbid (n=81), and control (n=70) groups based on levels of symptoms. Consistent with normative developmental trends across this age range, steep growth in depression was exhibited by all groups, including those who reported only CPs at study entry. In contrast, growth in CPs was restricted to those who reported high symptoms at intake (with or without comorbid depression), compared with low and stable among depressed only and control participants. To our knowledge, this is the first study to demonstrate, using carefully ascertained “pure” versus comorbid groups who were followed naturalistically, that comorbid depression is likely to develop among those with pure CPs, but comorbid CPs are not likely to develop among those with pure depression.
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影响因子：
5.9
作者：
Beauchaine, TP;Webster-Stratton, C;Reid, MJ
通讯作者：
Reid, MJ
DOI：
10.1111/j.1469-7610.2006.01625.x
发表时间：
2006-08-01
影响因子：
7.6
作者：
Drabick, Deborah A. G.;Gadow, Kenneth D.;Sprafkin, Joyce
通讯作者：
Sprafkin, Joyce
DOI：
10.1016/j.jaac.2010.01.016
发表时间：
2010-05-01
影响因子：
13.3
作者：
Burke, Jeffrey D.;Hipwell, Alison E.;Loeber, Rolf
通讯作者：
Loeber, Rolf
重新定义内表型概念以适应跨诊断的脆弱性和病因学的复杂性。
影响因子：
2.2
作者：
Beauchaine TP;Constantino JN
通讯作者：
Constantino JN
青少年共同出现的内在化和外部化疾病的结构和病因。
影响因子：
3.6
作者：
Cosgrove, Victoria E.;Rhee, Soo H.;Gelhorn, Heather L.;Boeldt, Debra;Corley, Robin C.;Ehringer, Marissa A.;Young, Susan E.;Hewitt, John K.
通讯作者：
Hewitt, John K.