Cerebral blood flow in 5- to 8-month-olds: Regional tissue maturity is associated with infant affect.
Cerebral blood flow in 5- to 8-month-olds: Regional tissue maturity is associated with infant affect.
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DOI：
10.1111/desc.12928
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发表时间：
2020-09
影响因子：
3.7
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Catalina Camacho M;King LS;Ojha A;Garcia CM;Sisk LM;Cichocki AC;Humphreys KL;Gotlib IH
婴儿期的特点是神经和情感发育迅速。然而，婴儿期大脑功能和情绪之间的关系还没有得到很好的理解。测量脑功能的方法主要依赖于BOLD信号;然而，婴儿期BOLD信号的解释是具有挑战性的，因为神经元-血流动力学关系还不成熟。局部脑血流量（rCBF）为婴儿BOLD信号提供了一个背景，并可以深入了解可能支持情感行为的大脑区域的发育成熟度。本研究旨在探讨婴儿期rCBF与年龄、情绪的关系。107名母亲报告了其婴儿的气质（婴儿年龄M ± SD = 6.14 ± 0.51个月）。婴儿的子样本完成MRI扫描，其中38人在自然睡眠期间产生可用的灌注MRI，以量化rCBF。母婴二对完成了重复的静止面孔范式，从婴儿的情绪反应和恢复压力进行了量化。我们测试了扫描时婴儿年龄、气质因子评分的相关性，并观察了体素rCBF的情感反应和恢复。婴儿年龄与CBF在几乎所有体素呈正相关，峰值位于感觉皮层和腹侧前额叶皮层，支持制定的rCBF是组织成熟度的指标。在几个皮质和皮质下边缘区，包括眶额皮质和额下回，气质负性情绪和积极情绪的恢复与rCBF呈正相关。这一发现使我们对婴儿期情感神经发育的本质有了更深入的了解。具体来说，前额叶皮层成熟度相对提高的婴儿可能会在日常生活中表现出更大的负面情绪和负面反应，但在社会压力源之后，积极情绪的恢复情况会更好。
Infancy is marked by rapid neural and emotional development. The relation between brain function and emotion in infancy, however, is not well understood. Methods for measuring brain function predominantly rely on the BOLD signal; however, interpretation of the BOLD signal in infancy is challenging because the neuronal-hemodynamic relation is immature. Regional cerebral blood flow (rCBF) provides a context for the infant BOLD signal and can yield insight into the developmental maturity of brain regions that may support affective behaviors. This study aims to elucidate the relations among rCBF, age, and emotion in infancy. One hundred and seven mothers reported their infants’ (infant age M ± SD = 6.14 ± 0.51 months) temperament. A subsample of infants completed MRI scans, 38 of whom produced usable perfusion MRI during natural sleep to quantify rCBF. Mother-infant dyads completed the repeated Still-Face Paradigm, from which infant affect reactivity and recovery to stress were quantified. We tested associations of infant age at scan, temperament factor scores, and observed affect reactivity and recovery with voxel-wise rCBF. Infant age was positively associated with CBF in nearly all voxels, with peaks located in sensory cortices and the ventral prefrontal cortex, supporting the formulation that rCBF is an indicator of tissue maturity. Temperamental Negative Affect and recovery of positive affect following a stressor were positively associated with rCBF in several cortical and subcortical limbic regions, including the orbitofrontal cortex and inferior frontal gyrus. This finding yields insight into the nature of affective neurodevelopment during infancy. Specifically, infants with relatively increased prefrontal cortex maturity may evidence a disposition toward greater negative affect and negative reactivity in their daily lives yet show better recovery of positive affect following a social stressor.
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影响因子：
5.7
作者：
Arichi, Tomoki;Fagiolo, Gianlorenzo;Varela, Marta;Melendez-Calderon, Alejandro;Allievi, Alessandro;Merchant, Nazakat;Tusor, Nora;Counsell, Serena J.;Burdet, Etienne;Beckmann, Christian F.;Edwards, A. David
通讯作者：
Edwards, A. David
影响因子：
25
作者：
Damasio, AR;Grabowski, TJ;Hichwa, RD
通讯作者：
Hichwa, RD
影响因子：
5.7
作者：
Camacho, M. Catalina;Karim, Helmet T.;Perlman, Susan B.
通讯作者：
Perlman, Susan B.
影响因子：
16.6
作者：
Deen B;Richardson H;Dilks DD;Takahashi A;Keil B;Wald LL;Kanwisher N;Saxe R
通讯作者：
Saxe R
影响因子：
4.7
作者：
Ahmed SP;Bittencourt-Hewitt A;Sebastian CL
通讯作者：
Sebastian CL