Ginsenoside from ginseng: a promising treatment for inflammatory bowel disease.
Ginsenoside from ginseng: a promising treatment for inflammatory bowel disease.
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人参中的人参皂苷：有望治疗炎症性肠病
DOI：
10.1007/s43440-020-00213-z
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Liu D
中科院分区：
文献类型：
--
作者：
Kang Z;Zhonga Y;Wu T;Huang J;Zhao H;Liu D
炎症性肠病（Inflammatory bowel disease，IBD）是一种由免疫紊乱介导的自身免疫性疾病，被世界卫生组织列为世界上最难治的疾病之一。在过去的半个世纪里，其发病率在全世界稳步上升。环境、遗传、感染和免疫因素是IBD发病机制的组成部分。人参通常被称为草药之王，在过去的2000年里，许多国家都在食用人参。其有效成分人参皂苷作为人参中最突出的皂苷，具有广泛的药理作用。近年来研究证实，人参的活性成分对IBD具有抗炎和免疫调节作用，包括调节免疫细胞平衡，抑制细胞因子的表达，以及激活Toll样受体4、核因子-κ B（NF-κB）、核苷酸结合寡聚化结构域样受体（NLRP）、丝裂原活化蛋白激酶信号传导、越来越多的证据表明，黄芪总皂苷有可能作为一种新型的治疗药物或保健品添加剂用于IBD的预防和治疗。
Inflammatory bowel disease (IBD) is an autoimmune disease mediated by immune disorder and termed as one of the most refractory diseases by the Word Health Organization. Its morbidity has increased steadily over the past half century worldwide. Environmental, genetic, infectious, and immune factors are integral to the pathogenesis of IBD. Commonly known as the king of herbs, ginseng has been consumed in many countries for the past 2000 years. Its active ingredient ginsenosides, as the most prominent saponins of ginseng, have a wide range of pharmacological effects. Recent studies have confirmed that the active components of Panax ginseng have anti-inflammatory and immunomodulatory effects on IBD, including regulating the balance of immune cells, inhibiting the expression of cytokines, as well as activating Toll-like receptor 4, Nuclear factor-kappa B (NF-κB), nucleotide-binding oligomerization domain-like receptor (NLRP), mitogen-activated protein kinase signaling, and so on. Accumulated evidence indicates that ginsenosides may serve as a potential novel therapeutic drug or health product additive in IBD prevention and treatment in the future.
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