Mental Health in Childhood and Adolescence: The Role of Polyunsaturated Fatty Acids.
Mental Health in Childhood and Adolescence: The Role of Polyunsaturated Fatty Acids.
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DOI：
10.3390/biomedicines9080850
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发表时间：
2021-07-21
期刊：
影响因子：
4.7
通讯作者：
Bellino S
中科院分区：
文献类型：
--
作者：
Bozzatello P;Blua C;Rocca P;Bellino S
人们越来越意识到多不饱和脂肪酸(PUFAs)对大脑最佳发育和功能的重要性。近几十年来，研究人员证实了多不饱和脂肪酸在多种病理生理过程中的核心作用。这些药物调节脑细胞信号传递机制，包括多巴胺能和5-羟色胺能通路。因此，多不饱和脂肪酸的营养不足可能会对大脑发育和发育结果产生不利影响。N-3PUFAs在精神分裂症、抑郁症、双相情感障碍、焦虑症、强迫症、创伤后应激障碍、注意缺陷多动障碍(ADHD)、自闭症谱系障碍、进食障碍、物质使用障碍和边缘人格障碍中的作用已被研究。与在成人中进行的大量研究相比，关于n-3多不饱和脂肪酸补充剂对患有精神障碍或表现出精神障碍高风险的儿童和青少年的影响的数据有限。这篇综述的目的是提供一个完整和最新的关于多不饱和脂肪酸对儿童和青少年发展精神病理学的影响的现有证据，以及在发育里程碑期间补充脂肪酸的影响，特别是在具有轻微但可检测到的精神障碍迹象或症状的儿童的高危人群中。
There is increasing awareness of the importance of polyunsaturated fatty acids (PUFAs) for optimal brain development and function. In recent decades, researchers have confirmed the central role of PUFAs in a variety of patho-physiological processes. These agents modulate the mechanisms of brain cell signalling including the dopaminergic and serotonergic pathways. Therefore, nutritional insufficiencies of PUFAs may have adverse effects on brain development and developmental outcomes. The role of n-3 PUFAs has been studied in several psychiatric disorders in adulthood: schizophrenia, major depression, bipolar disorder, anxiety disorders, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder (ADHD), autism spectrum disorders, eating disorders, substance use disorder, and borderline personality disorder. In contrast to the great number of studies conducted in adults, there are only limited data on the effects of n-3 PUFA supplementation in children and adolescents who suffer from mental disorders or show a high risk of developing psychiatric disorders. The aim of this review is to provide a complete and updated account of the available evidence of the impact of polyunsaturated fatty acids on developmental psychopathology in children and adolescents and the effect of fatty acid supplementation during developmental milestones, particularly in high-risk populations of children with minimal but detectable signs or symptoms of mental disorders.
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影响因子：
5.6
作者：
Bozzatello P;De Rosa ML;Rocca P;Bellino S
通讯作者：
Bellino S
影响因子：
10.6
作者：
Bazan NG
通讯作者：
Bazan NG
DOI：
10.1016/j.plefa.2006.02.001
发表时间：
2006-04-01
影响因子：
3
作者：
Bu, B;Ashwood, P;Jin, LW
通讯作者：
Jin, LW
影响因子：
--
作者：
Amminger, G. Paul;Schafer, Miriam R.;Berger, Gregor E.
通讯作者：
Berger, Gregor E.
影响因子：
10.6
作者：
Bentsen, Havard;Solberg, Dag K.;Lingjaerde, Odd
通讯作者：
Lingjaerde, Odd