Damage model of bone under mechanical and electromagnetic loadings
Damage model of bone under mechanical and electromagnetic loadings
复制标题
机械和电磁载荷下的骨损伤模型
DOI：
10.1016/j.commatsci.2011.06.037
复制
发表时间：
2012-05
影响因子：
3.3
通讯作者：
曲传咏
中科院分区：
文献类型：
--
作者：
曲传咏
骨作为一种活组织，具有一种与普通工程材料截然不同的惊人特性，到目前为止，我们还无法将其植入人造材料：它可以自我修复。这种更新过程是通过骨重建来实现的，但骨重建的功能远远不止修复受损的骨组织。骨骼还可以调整其内部微结构，从而使其机械性能适应不同的机械和生理环境。因此，骨损伤行为容易受到多种因素的影响。在本文中，我们建立了一个基于机理的损伤模型，以合理地描述在机械和电磁场同时作用下骨的损伤演化规律。该模型包含了骨组织复杂的损伤、重塑和愈合过程中的一些关键的物理和生物学机制。特别是提出了骨损伤的演化规律和相应的建模方法，用于分析多场作用下复杂的骨损伤/修复行为。给出了几个有代表性的例子，验证了所提出的理论模型在模拟环境载荷对骨损伤和修复的影响方面的应用。结果表明，该模型能很好地描述骨如何抵抗超载引起的损伤积累，以及极端超载是如何引起骨应力性断裂的。我们还研究了电磁场在骨重建中所起的作用。
Bone, as a living tissue, has an amazing property which is distinctly different from common engineering materials and up to now we have not been able to build into artificial materials: it can repair itself. This renewing process is performed by bone remodeling, but the functions of bone remodeling are far more than repairing the damaged bone tissue. Bone can also adapt its internal microstructure and, subsequently, mechanical properties to the varying mechanical and physiological environments. So the bone damage behavior can be easily influenced by many factors. In the present paper, we establish a mechanism-based damage model to rationalize the damage evolution law of bone under simultaneously applied mechanical and electromagnetic fields. Some crucial physical and biological mechanisms underlying the sophisticated damage, remodeling and healing process of bone tissues have been incorporated in the model. Especially, an evolutionary law of bone damage and the corresponding modeling methodology are presented to analyze the complicated damage/repair behavior of bone under multi-fields. Several representative examples are given to verify the application of the proposed theoretical model in modeling the effects of environmental loadings on bone damage and repair. The results demonstrate that this model can well describe how the bone resists the damage accumulation induced by overloading and how the extreme overloading causes stress fracture of bone. We also study the role which electromagnetic fields play in bone remodeling.
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影响因子：
4.1
作者：
M. Weinreb;I. Suponitzky;S. Keila
通讯作者：
M. Weinreb;I. Suponitzky;S. Keila
影响因子：
2.4
作者：
Hazenberg, Jan G.;Freeley, Michael;Taylor, David
通讯作者：
Taylor, David
影响因子：
2.4
作者：
Lee, TC;Staines, A;Taylor, D
通讯作者：
Taylor, D
影响因子：
7.6
作者：
Masazumi Nagai;Minoru Ota
通讯作者：
Masazumi Nagai;Minoru Ota
影响因子：
6
作者：
D. Taylor;T. C. Lee
通讯作者：
D. Taylor;T. C. Lee