Assemblies of Perisomatic GABAergic Neurons in the Developing Barrel Cortex.
Assemblies of Perisomatic GABAergic Neurons in the Developing Barrel Cortex.
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DOI：
10.1016/j.neuron.2019.10.007
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发表时间：
2020-01-08
期刊：
影响因子：
16.2
通讯作者：
Cossart R
中科院分区：
文献类型：
--
作者：
Modol L;Bollmann Y;Tressard T;Baude A;Che A;Duan ZRS;Babij R;De Marco García NV;Cossart R
皮层中间神经元的发育历程遇到了几个活动依赖的里程碑。在发育中的小鼠出生后早期，gaba能神经元是丘脑输入的短暂优先接受者，并经历活动依赖的迁移停止、连接和程序性细胞死亡。尽管gaba能神经元对感觉体验的出现和它们整合到皮质网络中的活动的作用很重要，但在新生儿时期gaba能神经元的集体动态仍然未知。在此，我们利用体内钙显像技术研究了小鼠桶状皮质gaba能细胞的协同活动。我们发现了gaba能种群动态中的一个瞬时结构，它在一个依赖感觉的过程中消失。它的组成部分是解剖学上聚集的gaba能组装体，主要由未来的小蛋白表达细胞组成。它们逐渐扩大它们的领土，直到形成一个统一的周边GABAergic网络。这种短暂的gaba能活动模式是一种功能性支架，在积极探索之前将皮层与外部世界联系起来。Modol等人利用桶状皮质的体内成像显示，未来的小白蛋白中间神经元形成了在出生后发育过程中合并的相关活动斑块。这些组合由须输入调节，并因感觉剥夺而改变。
The developmental journey of cortical interneurons encounters several activity-dependent milestones. During the early postnatal period in developing mice, GABAergic neurons are transient preferential recipients of thalamic inputs and undergo activity-dependent migration arrest, wiring, and programmed cell-death. Despite their importance for the emergence of sensory experience and the role of activity in their integration into cortical networks, the collective dynamics of GABAergic neurons during that neonatal period remain unknown. Here, we study coordinated activity in GABAergic cells of the mouse barrel cortex using in vivo calcium imaging. We uncover a transient structure in GABAergic population dynamics that disappears in a sensory-dependent process. Its building blocks are anatomically clustered GABAergic assemblies mostly composed by prospective parvalbumin-expressing cells. These progressively widen their territories until forming a uniform perisomatic GABAergic network. Such transient patterning of GABAergic activity is a functional scaffold that links the cortex to the external world prior to active exploration. Using in vivo imaging in the barrel cortex, Modol et al. show that prospective parvalbumin interneurons form patches of correlated activity that merge during postnatal development. These assemblies are regulated by whisker inputs and altered by sensory deprivation.
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