Manual Therapy Facilitates Homeostatic Adaptation to Bone Microstructural Declines Induced by a Rat Model of Repetitive Forceful Task.
Manual Therapy Facilitates Homeostatic Adaptation to Bone Microstructural Declines Induced by a Rat Model of Repetitive Forceful Task.
复制标题
DOI：
10.3390/ijms23126586
复制
发表时间：
2022-06-13
影响因子：
5.6
通讯作者：
Bove, Geoffrey M.
中科院分区：
文献类型：
--
作者：
Barbe, Mary F.;Amin, Mamta;Harris, Michele Y.;Panibatla, Siva Tejaa;Assari, Soroush;Popoff, Steven N.;Bove, Geoffrey M.
关键词：
手工疗法的有效性，以减少执行重复性的高强度的力量任务对骨骼的分解代谢的影响尚未报道。我们研究了手工治疗是否可以减少成年雌性Sprague-Dawley大鼠进行为期12周的高重复和高强度任务时桡骨微结构的下降，同时对前肢进行手工治疗或不进行手工治疗。额外的大鼠在任务停止后给予6周的休息，有或没有手工治疗。对照组大鼠不予治疗或采用手工治疗12周。未处理的TASK大鼠桡骨分解代谢指数增加（骨小梁体积和数量减少，骨小梁破骨细胞增加，骨干中部皮质骨变薄），血清CTX-1、TNF-α和肌肉巨噬细胞增加。相比之下，接受手工治疗的TASK大鼠桡骨合成代谢增加（小梁骨体积和成骨细胞数量增加，破骨细胞数量减少，骨干中部总面积和骨膜周长增加），血清TNF-α和肌肉巨噬细胞增加。休息，有或没有手工治疗，改善小梁厚度和中骨干皮质骨属性，但没有矿物质密度。因此，预防性手工治疗通过增加成骨来减少净桡骨分解代谢，而休息，有或没有手工治疗，效果较差。
The effectiveness of manual therapy in reducing the catabolic effects of performing repetitive intensive force tasks on bones has not been reported. We examined if manual therapy could reduce radial bone microstructural declines in adult female Sprague–Dawley rats performing a 12-week high-repetition and high-force task, with or without simultaneous manual therapy to forelimbs. Additional rats were provided 6 weeks of rest after task cessation, with or without manual therapy. The control rats were untreated or received manual therapy for 12 weeks. The untreated TASK rats showed increased catabolic indices in the radius (decreased trabecular bone volume and numbers, increased osteoclasts in these trabeculae, and mid-diaphyseal cortical bone thinning) and increased serum CTX-1, TNF-α, and muscle macrophages. In contrast, the TASK rats receiving manual therapy showed increased radial bone anabolism (increased trabecular bone volume and osteoblast numbers, decreased osteoclast numbers, and increased mid-diaphyseal total area and periosteal perimeter) and increased serum TNF-α and muscle macrophages. Rest, with or without manual therapy, improved the trabecular thickness and mid-diaphyseal cortical bone attributes but not the mineral density. Thus, preventive manual therapy reduced the net radial bone catabolism by increasing osteogenesis, while rest, with or without manual therapy, was less effective.
登录
查看更多内容
影响因子：
4.1
作者：
Butterfield TA;Zhao Y;Agarwal S;Haq F;Best TM
通讯作者：
Best TM
影响因子：
4.9
作者：
Dale, Ann Marie;Ryan, Daniel;Evanoff, Bradley
通讯作者：
Evanoff, Bradley
影响因子：
4.2
作者：
Dunlop, J. W. C.;Hartmann, M. A.;Brechet, Y. J.;Fratzl, P.;Weinkamer, R.
通讯作者：
Weinkamer, R.
影响因子：
6.2
作者：
Barr, AE;Safadi, FF;Barbe, MF
通讯作者：
Barbe, MF
影响因子：
2.9
作者：
Barbe MF;Amin M;Gingery A;Lambi AG;Popoff SN
通讯作者：
Popoff SN