The microRNA analysis portal is a next-generation tool for exploring and analyzing miRNA-focused data in the literature.
The microRNA analysis portal is a next-generation tool for exploring and analyzing miRNA-focused data in the literature.
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DOI：
10.1038/s41598-021-88617-6
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发表时间：
2021-04-26
影响因子：
4.6
通讯作者：
Galgani A
中科院分区：
文献类型：
--
作者：
Pirrò S;Matic I;Colizzi V;Galgani A
MicroRNAs是一类非编码小rna，参与许多生物通路的转录后调控。近年来，microrna也与跨王国的调控有关，表明外源性mirna可以在哺乳动物中以类似于哺乳动物mirna的方式发挥作用。人们对microrna的兴趣日益浓厚，文献和分子生物医学数据的数量也越来越多，这使得识别感兴趣的记录和跟上新发现的步伐变得困难。基于这些原因，我们开发了microRNA分析门户（MAP）。MAP从PubMed中选择与mirna相关的文章，链接生物医学和分子数据，并应用生物信息学模块。在撰写本文时，MAP代表了最丰富，最完整和集成的microrna数据库。MAP还集成了一个更新版本的MirCompare(2.0)，这是一个计算平台，用于根据植物microrna调节哺乳动物基因的能力来选择它们。MAP和MirCompare功能都被用来预测辣木的microrna通过调节人类免疫系统蛋白质编码基因在各个王国中具有假定的作用。MirCompare从94个人类microrna中选择了6个辣木的功能同源物。随后对人类靶点和功能富集区域的预测强调了这些基因在调节免疫系统过程中的核心参与，特别是在乙型肝炎、巨细胞病毒、乳头状瘤病毒和冠状病毒的宿主-病毒相互作用过程中。这个使用案例展示了MAP如何在没有任何计算背景的情况下帮助执行复杂查询。MAP可在http://stablab.uniroma2.it/MAP上获得。
MicroRNAs constitute a class of noncoding small RNAs involved in the posttranscriptional regulation of many biological pathways. In recent years, microRNAs have also been associated with regulation across kingdoms, demonstrating that exogenous miRNAs can function in mammals in a fashion similar to mammalian miRNAs. The growing interest in microRNAs and the increasing amount of literature and molecular and biomedical data available make it difficult to identify records of interest and keep up to date with novel findings. For these reasons, we developed the microRNA Analysis Portal (MAP). MAP selects relevant miRNA-focused articles from PubMed, links biomedical and molecular data and applies bioinformatics modules. At the time of this writing, MAP represents the richest, most complete and integrated database focused on microRNAs. MAP also integrates an updated version of MirCompare (2.0), a computational platform used for selecting plant microRNAs on the basis of their ability to regulate mammalian genes. Both MAP and MirCompare functionalities were used to predict that microRNAs from Moringa oleifera have putative roles across kingdoms by regulating human genes coding for proteins of the immune system. Starting from a selection of 94 human microRNAs, MirCompare selected 6 Moringa oleifera functional homologs. The subsequent prediction of human targets and areas of functional enrichment highlighted the central involvement of these genes in regulating immune system processes, particularly the host-virus interaction processes in hepatitis B, cytomegalovirus, papillomavirus and coronavirus. This case of use showed how MAP can help to perform complex queries without any computational background. MAP is available at http://stablab.uniroma2.it/MAP.
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