KLRG1+NKG2A+ CD8 T cells mediate protection and participate in memory responses during γ-herpesvirus infection.
KLRG1+NKG2A+ CD8 T cells mediate protection and participate in memory responses during γ-herpesvirus infection.
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DOI：
10.4049/jimmunol.1003122
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发表时间：
2011-04-01
期刊：
影响因子：
--
通讯作者：
Flaño E
中科院分区：
文献类型：
--
作者：
Cush SS;Flaño E
Functional CD8 T cell effector and memory responses are generated and maintained during murine γ-herpesvirus 68 (γHV68) persistent infection despite continuous presentation of viral lytic Ags. However, the identity of the CD8 T cell subpopulations that mediate effective recall responses and that can participate in the generation of protective memory to a γ-herpesvirus infection remains unknown. During γHV68 persistence, ~75% of γHV68-specific CD8 T cells coexpress the NK receptors killer cell lectin-like receptor G1 (KLRG1) and NKG2A. In this study, we take advantage of this unique phenotype to analyze the capacity of CD8 T cells expressing or not expressing KLRG1 and NKG2A to mediate effector and memory responses. Our results show that γHV68-specific KLRG1+NKG2A+ CD8 T cells have an effector memory phenotype as well as characteristics of polyfunctional effector cells such us IFN-γ and TNF-α production, killing capacity, and are more efficient at protecting against a γHV68 challenge than their NKG2A−KLRG1− counterparts. Nevertheless, γHV68-specific NKG2A+KLRG1+ CD8 T cells express IL-7 and IL-15 receptors, can survive long-term without cognate Ag, and subsequently mount a protective response during antigenic recall. These results highlight the plasticity of the immune system to generate protective effector and proliferative memory responses during virus persistence from a pool of KLRG1+NKG2A+ effector memory CD8 T cells.
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影响因子：
64.5
作者：
Kaech, SM;Hemby, S;Ahmed, R
通讯作者：
Ahmed, R
激活表型，而不是中心或效应子内存表型，可预测记忆CD8+ T细胞的回忆功效。
影响因子：
15.3
作者：
Hikono, Hirokazu;Kohlmeier, Jacob E.;Takamura, Shiki;Wittmer, Susan T.;Roberts, Alan D.;Woodland, David L.
通讯作者：
Woodland, David L.
影响因子：
4.4
作者：
Hogan, RJ;Usherwood, EJ;Woodland, DL
通讯作者：
Woodland, DL
影响因子：
30.5
作者：
Kaech, SM;Tan, JT;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
20.3
作者：
Henson, Sian M.;Franzese, Ornella;Akbar, Arne N.
通讯作者：
Akbar, Arne N.