Evaluation of the biocompatibility of root canal sealers using subcutaneous implants.
Evaluation of the biocompatibility of root canal sealers using subcutaneous implants.
复制标题
DOI：
10.1590/s1678-77572007000300007
复制
发表时间：
2007-06
期刊：
影响因子：
--
通讯作者：
Souza-Filho FJ
中科院分区：
文献类型：
--
作者：
Gomes-Filho JE;Gomes BP;Zaia AA;Ferraz CR;Souza-Filho FJ
本研究旨在评价Endomethasone、牙髓封闭剂EWT和AH-Plus根管封闭剂植入大鼠结缔组织后的体内生物相容性。使用24只Wistar-Furth大鼠。用密封剂填充聚乙烯管，并植入大鼠特定的背侧皮下组织部位。在3、7和30天后取出植入物，固定并进行甲基丙烯酸乙二醇酯包埋技术处理，以进行显微镜检查。在第3天，对髓腔封闭剂EWT植入物有轻度炎症反应，但对其他封闭剂有严重反应，存在急性炎症细胞。在第7天，组织组织化更加明显，炎症反应减弱，尤其是AH-Plus植入物。在第30天，观察到与所有植入物接触的结缔组织几乎没有炎症细胞。在该时间间隔内，与牙髓管封闭器EWT植入体接触的组织更加组织化，而与Endomethasone和AH-Plus植入体接近的组织显示出轻度持续性炎症反应，并且结果彼此相似。总之，密封剂具有相似的刺激模式，开始时更严重，随着时间的推移更轻微，所有密封剂均表现出持续的轻微反应。牙髓管封闭器EWT产生的组织比Endomethasone和AH-Plus更好，而Endomethasone和AH-Plus显示出彼此相似的结果。
The purpose of this study was to evaluate in vivo the biocompatibility of Endométhasone, Pulp Canal Sealer EWT and AH-Plus root canal sealers after implantation in rat connective tissue. Twenty-four Wistar-Furth rats were used. Polyethylene tubes were filled with the sealers and implanted into specific dorsal subdermal tissue sites of the rats. Implants were removed after 3, 7 and 30 days, fixed and processed for glycol methacrylate-embedding technique to be examined microscopically. On the 3rd day, there was a mild inflammatory reaction to Pulp Canal Sealer EWT implants, but a severe response to the other sealers with presence of acute inflammatory cells. On the 7th day, tissue organization was more evident with attenuation of the inflammatory reaction, especially for the AH-Plus implants. On the 30th day, connective tissue with few inflammatory cells was observed in contact with all sealer implants. In this time interval, the tissue in contact with Pulp Canal Sealer EWT implants was more organized, while the tissue close to Endométhasone and AH-Plus implants showed a mild persistent inflammatory reaction and had similar results to each other. In conclusion, the sealers had a similar pattern of irritation, which was more severe in the beginning and milder with time, in such a way that all sealers showed a persistent mild reaction. Pulp Canal Sealer EWT yielded better tissue organization than Endométhasone and AH-Plus, which, in turn, showed similar results to each other.
登录
查看更多内容
影响因子：
--
作者：
Gomes, Brenda Paula Figueiredo de Almeida;Pedroso, José Assis;Souza-Filho, Francisco José de
通讯作者：
Souza-Filho, Francisco José de
影响因子：
3
作者：
FEDER, N;OBRIEN, TP
通讯作者：
OBRIEN, TP
影响因子：
4.2
作者：
Gomes, JE;Gomes, BPFA;Souza, FJ
通讯作者：
Souza, FJ
影响因子：
5
作者：
Koch, MJ
通讯作者：
Koch, MJ
DOI：
10.1016/s1079-2104(99)70119-8
发表时间：
1999-08-01
影响因子：
--
作者：
Leonardo, MR;da Silva, LAB;da Silva, RS
通讯作者：
da Silva, RS