Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations.
Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations.
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DOI：
10.1111/j.1753-4887.2012.00508.x
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发表时间：
2012-09
影响因子：
6.1
通讯作者：
McCullough ML
中科院分区：
文献类型：
--
作者：
Peterson JJ;Dwyer JT;Jacques PF;McCullough ML
来自12个前瞻性队列的20篇出版物评估了欧洲和美国成年人中类黄酮摄入量与心血管疾病发病率或死亡率之间的关联。最常见的结果是冠心病死亡率，8项队列研究中有4项报告了至少一种黄酮类化合物的显著负相关性（多变量调整的p趋势<.05）。七个队列中有三个报告说，更多的类黄酮摄入量与较低的中风风险有关。比较是困难的，因为变异类黄酮包括，人口统计学特征的人群，评估的结果，和随访时间。最常见的黄酮类化合物是黄酮和黄酮醇的组合（11项研究）。只有一项研究检查了所有七种类黄酮。黄酮醇类和黄酮类与较低的CHD死亡率密切相关。保护其他类黄酮和CVD结果的证据更为有限。类黄酮摄入量与较低的CVD发病率和死亡率相关的假设需要进一步研究。
Twenty publications from twelve prospective cohorts evaluated associations between flavonoid intakes and incidence or mortality from cardiovascular disease among adults in Europe and the United States (US). The most common outcome was coronary heart disease mortality, and four of eight cohort studies reported significant inverse associations for at least one flavonoid class (multivariate adjusted ptrend <.05). Three of seven cohorts reported that greater flavonoid intake was associated with lower risk of incident stroke. Comparisons were difficult because of variability in the flavonoid classes included, demographic characteristics of the populations, outcomes assessed, and length of follow up. The most common flavonoid classes examined were flavones and flavonols combined (11 studies). Only one study examined all seven flavonoid classes. The flavonol and flavone classes were most strongly associated with lower CHD mortality. Evidence for protection from other flavonoid classes and CVD outcomes was more limited. The hypothesis that flavonoid intakes are associated with lower CVD incidence and mortality requires further study.
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影响因子：
3.2
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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