High times for cannabis: Epigenetic imprint and its legacy on brain and behavior.
High times for cannabis: Epigenetic imprint and its legacy on brain and behavior.
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DOI：
10.1016/j.neubiorev.2017.05.011
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发表时间：
2018-03
影响因子：
8.2
通讯作者：
Hurd YL
中科院分区：
文献类型：
--
作者：
Szutorisz H;Hurd YL
Extensive debates continue regarding marijuana (Cannabis spp), the most commonly used illicit substance in many countries worldwide. There has been an exponential increase of cannabis studies over the past two decades but the drug’s long-term effects still lack in-depth scientific data. The epigenome is a critical molecular machinery with the capacity to maintain persistent alterations of gene expression and behaviors induced by cannabinoids that have been observed across the individual’s lifespan and even into the subsequent generation. Though mechanistic investigations regarding the consequences of developmental cannabis exposure remain sparse, human and animal studies have begun to reveal specific epigenetic disruptions in the brain and the periphery. In this article, we focus attention on long-term disturbances in epigenetic regulation in relation to prenatal, adolescent and parental germline cannabinoid exposure. Expanding knowledge about the protracted molecular memory could help to identify novel targets to develop preventive strategies and treatments for behaviors relevant to neuropsychiatric risks associated with developmental cannabis exposure.
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影响因子：
6.8
作者：
Cecil CA;Walton E;Smith RG;Viding E;McCrory EJ;Relton CL;Suderman M;Pingault JB;McArdle W;Gaunt TR;Mill J;Barker ED
通讯作者：
Barker ED
影响因子：
4.8
作者：
Chioccarelli, Teresa;Cacciola, Giovanna;Cobellis, Gilda
通讯作者：
Cobellis, Gilda
DOI：
10.1002/bdrb.20295
发表时间：
2011-06-01
影响因子：
--
作者：
Banerjee, Arnab;Singh, Ajit;Krishna, Amitabh
通讯作者：
Krishna, Amitabh
影响因子：
3.1
作者：
Bari, Monica;Battista, Natalia;Maccarrone, Mauro
通讯作者：
Maccarrone, Mauro
影响因子：
3.4
作者：
Anker, Justin J.;Carroll, Marilyn E.
通讯作者：
Carroll, Marilyn E.