Effect of Tea Catechins on Influenza Infection and the Common Cold with a Focus on Epidemiological/Clinical Studies.
Effect of Tea Catechins on Influenza Infection and the Common Cold with a Focus on Epidemiological/Clinical Studies.
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DOI：
10.3390/molecules23071795
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发表时间：
2018-07-20
期刊：
影响因子：
--
通讯作者：
Yamada H
中科院分区：
文献类型：
--
作者：
Furushima D;Ide K;Yamada H
流行性感冒和普通感冒是急性呼吸道传染病。流感是一种严重的疾病，传染性极强，病情加重时可发展为肺炎或脑炎等危及生命的疾病。由于流感感染和普通感冒很容易通过飞沫和接触传播，因此建议采取洗手和戴口罩等公共预防措施来预防流感。实验研究表明，茶儿茶素可抑制流感病毒吸附并抑制复制和神经氨酸酶活性。它们对某些感冒病毒也有效。此外，茶中的儿茶素还能增强抵抗病毒感染的免疫力。尽管茶儿茶素的抗病毒活性已得到证实，但支持其效用的临床证据仍不确定。自 20 世纪 90 年代末以来，多项流行病学研究表明，经常饮用绿茶可以降低流感感染率和一些感冒症状，而用茶儿茶素漱口可以预防流感感染。本综述简要总结了茶儿茶素对流感感染和普通感冒的影响，重点是流行病学/临床研究，并阐明需要进一步研究以证实其临床疗效。
Influenza and the common cold are acute infectious diseases of the respiratory tract. Influenza is a severe disease that is highly infectious and can progress to life-threating diseases such as pneumonia or encephalitis when aggravated. Due to the fact that influenza infections and common colds spread easily via droplets and contact, public prevention measures, such as hand washing and facial masks, are recommended for influenza prophylaxis. Experimental studies have reported that tea catechins inhibited influenza viral adsorption and suppressed replication and neuraminidase activity. They were also effective against some cold viruses. In addition, tea catechins enhance immunity against viral infection. Although the antiviral activity of tea catechins has been demonstrated, the clinical evidence to support their utility remains inconclusive. Since the late 1990s, several epidemiological studies have suggested that the regular consumption of green tea decreases influenza infection rates and some cold symptoms, and that gargling with tea catechin may protect against the development of influenza infection. This review briefly summarizes the effect of tea catechins on influenza infection and the common cold with a focus on epidemiological/clinical studies, and clarifies the need for further studies to confirm their clinical efficacy.
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