Phylogeography of Ascaris lumbricoides and A. suum from China
Phylogeography of Ascaris lumbricoides and A. suum from China
复制标题
中国蛔虫和猪蛔虫的系统发育地理学
DOI：
10.1007/s00436-011-2260-4
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发表时间：
2011-02
影响因子：
2
通讯作者：
Peng, Weidong
中科院分区：
文献类型：
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作者：
Zhou, Chunhua;Li, Min;Yuan, Keng;Hu, Ningyan;Peng, Weidong
为了进一步了解人和猪蛔虫的遗传结构和进化关系，利用线粒体DNA分子标记(细胞色素C氧化酶亚基1和NAD1)和DNASP5.0、Arlequin 3.0、MEGA 4.0和NETWORK 4.5.1.6软件对中国6个流行区的12个种群进行了系统地理学研究。结果表明：(A)不同宿主和不同地点的蛔虫遗传多样性不同，但没有明显的地理分布格局；(B)猪源人群的遗传多样性和分化水平高于人源人群，南方地区人群的遗传多样性和分化水平高于中北部地区的人群，但猪源人群没有发现类似的地理差异；(C)大部分人源蛔虫群体存在历史种群扩张，而猪源人群没有。(D)在人和猪来源的蛔虫之间以及在人来源的人群中检测到高水平的基因流动，(E)COX1单倍型的网络分析表明人类来源的蛔虫是祖先的单倍型。综上所述，本研究从遗传多样性、种群分化和历史人口学模式、基因流动、系统发育重建和单倍型网络等方面揭示了蛔虫的新信息，并与中国人的历史人口迁徙和野猪驯化的结果进行了讨论，对两种蛔虫的进化关系提出了不同的假设。本研究对人和猪蛔虫的流行病学和进化分类关系有一定的启示。
In order to obtain further understanding of genetic structure and evolutionary relationship of Ascaris from humans and pigs, phylogeography study on 12 populations from six endemic regions in China was conducted using mitochondrial DNA markers (cytochrome c oxidase subunit 1 (COX1) and NAD1) and the software programs of DnaSP 5.0, Arlequin 3.0, MEGA 4.0, and NETWORK 4.5.1.6. Results showed that (a) genetic diversity of Ascaris varied with hosts and locations, but no distinct geographical distribution pattern was found, (b) a higher level of genetic diversity and differentiation was found in pig-derived populations in contrast to human-derived ones, and in populations of human-derived Ascaris from the southern regions in comparison to that from the middle and northern locations, but similar geographical difference was not observed within pig-derived populations, (c) historical population expanding was detected from a large part of human-derived Ascaris populations but not in pig-derived Ascaris, (d) a high level of gene flow was detected between human- and pig-derived Ascaris and also among human-derived populations, and (e) network analysis from haplotype of COX1 indicated an ancestral haplotype from human-derived Ascaris. In conclusion, the present study revealed new information on Ascaris on the aspects of genetic diversity, population differentiation and historical demographic patterns, gene flow, phylogenesis reconstruction, and haplotype network, discussed the results with historical demographic migration of humans and domestication of wild boar in China, and raised a different assumption about the evolutionary relationship of the two roundworms. This study should have certain enlightenment for the epidemiology and the evolutionary and taxonomy relationship of Ascaris from humans and pigs.
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DOI：
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发表时间：
2003-03
期刊：
Yi chuan xue bao = Acta genetica Sinica
影响因子：
--
作者：
Gui-Xiang Zhang;Zhiguo Wang;Fei-Zhou Sun;Weisheng Chen;Guo-Yi Yang;Shixing Guo;Yong-jun Li;Xiao-Li Zhao;Yuan Zhang;Jun Sun;B. Fan;Shulin Yang;Kui Li
通讯作者：
Gui-Xiang Zhang;Zhiguo Wang;Fei-Zhou Sun;Weisheng Chen;Guo-Yi Yang;Shixing Guo;Yong-jun Li;Xiao-Li Zhao;Yuan Zhang;Jun Sun;B. Fan;Shulin Yang;Kui Li
影响因子：
3.3
作者：
F. Tajima
通讯作者：
F. Tajima
影响因子：
3.3
作者：
S. Schneider;L. Excoffier
通讯作者：
S. Schneider;L. Excoffier
DOI：
--
发表时间：
1984
期刊：
--
影响因子：
--
作者：
Hu Sy
通讯作者：
Hu Sy
影响因子：
3.3
作者：
Allan Larson;David B. Wake;Kay P. Yanev
通讯作者：
Allan Larson;David B. Wake;Kay P. Yanev