Impact of body mass index on in-hospital mortality for six acute cardiovascular diseases in Japan.
Impact of body mass index on in-hospital mortality for six acute cardiovascular diseases in Japan.
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DOI：
10.1038/s41598-022-23354-y
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发表时间：
2022-11-07
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
亚洲和西方人群的体重指数（BMI）分布及其对心血管疾病（CVD）的影响各不相同。该研究旨在揭示日本CVD患者肥胖和体重不足患病率的时间相关趋势以及BMI的安全范围。我们分析了日本国家所有心脏和血管疾病登记处-诊断程序组合数据集随时间推移的5，020，464条记录（2012-2019年），并评价了BMI趋势和对6种急性心血管疾病住院死亡率的影响：急性心力衰竭（AHF）、急性心肌梗死（AMI）、急性主动脉夹层（AAD）、缺血性卒中（IS）、脑出血（ICH），和蛛网膜下腔出血（SAH）。使用WHO亚洲BMI标准将患者分为五组：体重不足（< 18.5 kg/m2）、正常（18.5-22.9 kg/m2）、超重风险（23.0-24.9 kg/m2）、肥胖I（25.0-29.9 kg/m2）和肥胖II（≥ 30.0 kg/m2）。年龄与所有疾病的高BMI均呈显著负相关（P < 0.001）。BMI类别的比例随着时间的推移发生了显着变化;年度BMI趋势显示出显着和逐渐增加，AAD除外。在校正的混合模型中，体重不足与所有CVD患者的住院死亡率高风险显著相关（AHF，OR 1.41，95% CI 1.35-1.48，P < 0.001; AMI，OR 1.27，95% CI 1.20-1.35，P < 0.001; AAD，OR 1.23，95% CI 1.16-1.32，P < 0.001; IS，OR 1.45，95%CI 1.41-1.50，P < 0.001; ICH，OR 1.18，95%CI 1.13-1.22，P < 0.001; SAH，OR 1.17，95%CI 1.10-1.26，P < 0.001）。此外，肥胖I和II组与较高的院内死亡率显著相关，AHF和IS除外。在6例CVD患者中，年龄与所有BMI类别的住院死亡率相关。6种心血管疾病患者的BMI每年都在增加。虽然体重过轻的BMI与高死亡率相关，但肥胖对住院死亡率的影响在CVD类型中有所不同。
Body mass index (BMI) distribution and its impact on cardiovascular disease (CVD) vary between Asian and western populations. The study aimed to reveal time-related trends in the prevalence of obesity and underweight and safe ranges of BMI in Japanese patients with CVD. We analyzed 5,020,464 records from the national Japanese Registry of All Cardiac and Vascular Diseases—Diagnosis Procedure Combination dataset over time (2012–2019) and evaluated BMI trends and the impact on in-hospital mortality for six acute CVDs: acute heart failure (AHF), acute myocardial infarction (AMI), acute aortic dissection (AAD), ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH). Patients were categorized into five groups using the WHO Asian-BMI criteria: underweight (< 18.5 kg/m2), normal (18.5–22.9 kg/m2), overweight at risk (23.0–24.9 kg/m2), obese I (25.0–29.9 kg/m2), and obese II (≥ 30.0 kg/m2). Age was significantly and inversely related to high BMI for all diseases (P < 0.001). The proportion of BMI categories significantly altered over time; annual BMI trends showed a significant and gradual increase, except AAD. In adjusted mixed models, underweight was significantly associated with a high risk of in-hospital mortality in all CVD patients (AHF, OR 1.41, 95% CI 1.35–1.48, P < 0.001; AMI, OR 1.27, 95% CI 1.20–1.35, P < 0.001; AAD, OR 1.23, 95% CI 1.16–1.32, P < 0.001; IS, OR 1.45, 95% CI 1.41–1.50, P < 0.001; ICH, OR 1.18, 95% CI 1.13–1.22, P < 0.001; SAH, OR 1.17, 95% CI 1.10–1.26, P < 0.001). Moreover, obese I and II groups were significantly associated with a higher incidence of in-hospital mortality, except AHF and IS. Age was associated with in-hospital mortality for all BMI categories in six CVD patients. BMI increased annually in patients with six types of CVDs. Although underweight BMI was associated with high mortality rates, the impact of obesity on in-hospital mortality differs among CVD types.
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影响因子：
158.5
作者：
Calle, EE;Thun, MJ;Heath, CW
通讯作者：
Heath, CW
影响因子：
24
作者：
Gadde KM;Martin CK;Berthoud HR;Heymsfield SB
通讯作者：
Heymsfield SB
DOI：
10.1038/s41569-018-0064-2
发表时间：
2018-09
期刊：
Nature reviews. Cardiology
影响因子：
--
作者：
Ferrucci L;Fabbri E
通讯作者：
Fabbri E
影响因子：
2.8
作者：
Balachandran, Arun;de Beer, Joop;Janssen, Fanny
通讯作者：
Janssen, Fanny
影响因子：
2
作者：
Miyazawa, Itsuko;Kadota, Aya;Ohnishi, Atsushi
通讯作者：
Ohnishi, Atsushi