Brain growth in the NICU: critical periods of tissue-specific expansion.
Brain growth in the NICU: critical periods of tissue-specific expansion.
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DOI：
10.1038/pr.2018.4
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发表时间：
2018-05
影响因子：
3.6
通讯作者：
Inder TE
中科院分区：
文献类型：
--
作者：
Matthews LG;Walsh BH;Knutsen C;Neil JJ;Smyser CD;Rogers CE;Inder TE
使用系列MRI检查VPT婴儿在妊娠晚期早期和晚期的总脑生长和组织特异性脑生长。从两个前瞻性队列的VPT婴儿（≤30周妊娠）中收集结构MRI扫描。18名VPT受试者的51次MRI扫描可用于体积分析。脑组织分为脑脊液、皮质灰质、有髓和无髓白色物质、深核灰质和小脑。9名婴儿进行了足够的连续扫描，以比较妊娠晚期早期和晚期的组织生长情况。子宫外脑生长轨迹的组织特异性差异在相应的第三个三个月期间观察到。最值得注意的是，从月经后34-40周开始，皮质灰质扩张显着增加，强调了大脑发育的这一关键时期。利用系列MRI记录VPT婴儿的早期大脑发育，本研究记录了在孕晚期的上半年和下半年期间子宫外大脑生长轨迹的区域差异，为NICU中快速扩张的皮质灰质的成熟脆弱性提供了新的见解。
To examine using serial MRI, total and tissue-specific brain growth in VPT infants during the period that coincides with the early and late stages of the third trimester. Structural MRI scans were collected from two prospective cohorts of VPT infants (≤30 weeks’ gestation). 51 MRI scans from 18 VPT subjects were available for volumetric analysis. Brain tissue was classified into cerebrospinal fluid, cortical grey matter, myelinated and unmyelinated white matter, deep nuclear grey matter, and cerebellum. Nine infants had sufficient serial scans to allow comparison of tissue growth during the periods corresponding to the early and late stages of the third trimester. Tissue-specific differences in ex-utero brain growth trajectories were observed in the period corresponding to the third trimester. Most notably, there was a marked increase in cortical grey matter expansion from 34–40 weeks’ postmenstrual age, emphasizing this critical period of brain development. Utilizing serial MRI to document early brain development in VPT infants, this study documents regional differences in brain growth trajectories ex-utero during the period corresponding to the first and second half of the third trimester, providing novel insight into the maturational vulnerability of the rapidly expanding cortical grey matter in the NICU.
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影响因子：
8
作者：
Murphy, BP;Inder, TE;Volpe, JJ
通讯作者：
Volpe, JJ
影响因子：
11.2
作者：
Hüppi, PS;Warfield, S;Volpe, JJ
通讯作者：
Volpe, JJ
影响因子：
5.3
作者：
HAUSER, KF;GURWELL, JA;TURBEK, CS
通讯作者：
TURBEK, CS
影响因子：
8
作者：
Ment LR;Kesler S;Vohr B;Katz KH;Baumgartner H;Schneider KC;Delancy S;Silbereis J;Duncan CC;Constable RT;Makuch RW;Reiss AL
通讯作者：
Reiss AL
影响因子：
1.1
作者：
Golalipour MJ;Ghafari S
通讯作者：
Ghafari S