Muscle adaptations in acute SCI following overground exoskeleton + FES training: A pilot study.

Muscle adaptations in acute SCI following overground exoskeleton + FES training: A pilot study.
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DOI:
10.3389/fresc.2022.963771
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发表时间:
2022
期刊:
FRONTIERS IN REHABILITATION SCIENCES
影响因子:
--
通讯作者:
Jayaraman, Arun
Jayaraman, Arun
中科院分区:
其他
文献类型:
--
作者:
Hohl, Kristen;Smith, Andrew C.;Macaluso, Rebecca;Giffhorn, Matthew;Prokup, Sara;O'Dell, Denise R.;Kleinschmidt, Lina;Elliott, Jim M.;Jayaraman, Arun

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评估机器人外骨骼和功能性电刺激(FES)训练对急性脊髓损伤(SCI)患者在地面步态训练期间肌肉组成的综合影响。随机交叉初步研究。住院康复医院。6例急性SCI患者。参与者被随机分配接受Ekso® Bionics外骨骼与FES结合的训练以及标准护理或单独标准护理。该研究的主要结局指标使用磁共振成像(MRI)进行量化,特别是下肢肌肉体积和肌内脂肪组织(IMAT)。使用贝格平衡量表评估静态平衡和跌倒风险。当与仅标准护理相比时,在外骨骼干预组中观察到肌肉体积的显著改善(p < 0.001)。尽管干预组的IMAT下降趋势具有统计学意义(p = 0.07),但两组之间的IMAT没有显著差异。两组的静态平衡都有所改善,干预组的改善更大。使用机器人外骨骼的早期干预可能有助于改善急性SCI患者的肌肉功能。
To evaluate the combined effects of robotic exoskeleton and functional electrical stimulation (FES) training on muscle composition during over-ground gait training in persons with acute spinal cord injury (SCI). Randomized crossover pilot study. Inpatient-rehabilitation Hospital. Six individuals with acute SCI. Participants were randomized to either receive training with the Ekso® Bionics exoskeleton combined with FES in addition to standard-of-care or standard-of-care alone. The main outcome measures for the study were quantified using magnetic resonance imaging (MRI), specifically, lower extremity muscle volume and intramuscular adipose tissue (IMAT). Static balance and fall risk were assessed using the Berg Balance Scale. Significant improvements were observed in muscle volume in the exoskeleton intervention group when compared to only standard-of-care (p < 0.001). There was no significant difference between the groups in IMAT even though the intervention group saw a reduction in IMAT that trended towards statistical significance (p = 0.07). Static balance improved in both groups, with greater improvements seen in the intervention group. Early intervention with robotic exoskeleton may contribute to improved muscle function measured using MRI in individuals with acute SCI.
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