Megadepth: efficient coverage quantification for BigWigs and BAMs.
Megadepth: efficient coverage quantification for BigWigs and BAMs.
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DOI:
10.1093/bioinformatics/btab152
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发表时间:
2021-09-29
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影响因子:
--
通讯作者:
Langmead B
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文献类型:
--
作者:
Wilks C;Ahmed O;Baker DN;Zhang D;Collado-Torres L;Langmead B
A common way to summarize sequencing datasets is to quantify data lying within genes or other genomic intervals. This can be slow and can require different tools for different input file types. Megadepth is a fast tool for quantifying alignments and coverage for BigWig and BAM/CRAM input files, using substantially less memory than the next-fastest competitor. Megadepth can summarize coverage within all disjoint intervals of the Gencode V35 gene annotation for more than 19 000 GTExV8 BigWig files in approximately 1 h using 32 threads. Megadepth is available both as a command-line tool and as an R/Bioconductor package providing much faster quantification compared to the rtracklayer package. https://github.com/ChristopherWilks/megadepth, https://bioconductor.org/packages/megadepth. Supplementary data are available at Bioinformatics online.
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影响因子:
13.6
作者:
Zhang, David;Guelfi, Sebastian;Ryten, Mina
通讯作者:
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DOI:
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发表时间:
2014-04-01
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
作者:
Zerbino DR;Johnson N;Juettemann T;Wilder SP;Flicek P
通讯作者:
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DOI:
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发表时间:
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期刊:
Bioinformatics (Oxford, England)
影响因子:
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作者:
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通讯作者:
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DOI:
10.1093/bioinformatics/btu056
发表时间:
2014-06-01
期刊:
Bioinformatics (Oxford, England)
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--
作者:
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通讯作者:
Beato M
影响因子:
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作者:
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