Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease.
Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease.
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DOI：
10.1016/j.hrtlng.2022.04.012
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发表时间：
2022-09
期刊：
影响因子：
2.8
通讯作者：
Mudd-Martin, Gia
中科院分区：
文献类型：
--
作者：
Key, Kaitlin Voigts;Estus, Steven;Lennie, Terry A.;Linares, Ana Maria;Mudd-Martin, Gia
种族歧视在美国拉丁裔社区中经常发生，并与心血管疾病的风险因素有关，如抑郁症。遗传变异可能会影响这种关系。本研究的目的是检查经验的歧视，rs 4680基因型和抑郁症状在拉丁美洲成年人之间的关联。我们分析了124名有两个或两个以上CVD危险因素的拉丁裔成年人的数据，并进行了分层线性回归，调整了性别，年龄，收入，教育和文化适应。参与者主要为女性（74.2%），年龄为40.2±9.3岁。更多的歧视经历与更高的抑郁症状相关（p=0.041）。Met-Met基因型和Val-Met基因型的抑郁症状比Val-Val基因型的抑郁症状更严重（p=0.049）。RS 4680不是主持人。研究结果表明，歧视和rs 4680基因型与拉丁裔成年人的抑郁症状相关，这可能会增加CVD风险。需要进一步的研究来更好地了解这些关系的生物学机制。
Ethnic discrimination is frequently experienced among U.S. Latinx communities, and is linked to CVD risk factors, such as depression. Genetic variants may influence this relationship. The objectives of this study were to examine associations between experiences of discrimination, rs4680 genotype, and depressive symptoms in Latinx adults. We analyzed data from 124 Latinx adults with two or more CVD risk factors, and conducted hierarchical linear regression, adjusting for sex, age, income, education, and acculturation. Participants were predominately female (74.2%) and aged 40.2±9.3 years. More experiences of discrimination were associated with higher depressive symptoms (p=0.041). Those with Met-Met and Val-Met genotypes had increased depressive symptoms than those with Val-Val genotype (p=0.049). Rs4680 was not a moderator. Findings suggest discrimination and rs4680 genotype are associated with depressive symptoms in Latinx adults, which may increase CVD risk. Further research is needed to better understand biological mechanisms of these relationships.
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影响因子：
7.4
作者：
Hosang, Georgina M.;Fisher, Helen L.;Farmer, Anne E.
通讯作者：
Farmer, Anne E.
DOI：
10.1016/j.ssmph.2016.11.003
发表时间：
2016-12
期刊：
SSM - population health
影响因子：
--
作者：
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Viruell-Fuentes E
影响因子：
6.6
作者：
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通讯作者：
Lavebratt, Catharina
影响因子：
5
作者：
Everson-Rose, Susan A.;Lutsey, Pamela L.;Roux, Ana V. Diez
通讯作者：
Roux, Ana V. Diez
影响因子：
2.7
作者：
Lu, Qiaohui;Mouri, Akihiro;Saito, Kuniaki
通讯作者：
Saito, Kuniaki