Effect of exercise and morphine on psychological and physical dependencies, BDNF and TrkB gene expression in rat's hippocampus.
Effect of exercise and morphine on psychological and physical dependencies, BDNF and TrkB gene expression in rat's hippocampus.
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DOI：
10.12669/pjms.333.12342
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发表时间：
2017-05
影响因子：
2.2
通讯作者：
Sajjadi SF
中科院分区：
文献类型：
--
作者：
Naghshvarian M;Zarrindast MR;Mehr SE;Ommati MM;Sajjadi SF
比较运动和吗啡对大鼠模型戒断综合征和海马基因表达的影响。 30 只成年雄性大鼠接受自愿轮式运动（低、中、高）28 天。受试者进入条件性场所偏好（CPP）装置并经历吗啡（低、中、高）CPP，然后进行纳洛酮测试。确定了运动水平、吗啡注射、同时吗啡给药和运动与吗啡 CPP、BDNF 和 TrkB 基因之间的相关性。对大鼠实施安乐死、斩首并切除海马体。通过实时PCR评估BDNF和TrkB基因的表达。活跃大鼠的平均跑步速度为 839.18 m/d。运动水平、吗啡注射、吗啡同时给药和运动与吗啡 CPP、BDNF 和 TrKB 基因表达之间存在显着相关性（P<0.001）。不同水平的自愿锻炼可增强大脑奖励系统、CPP 量表以及海马 BDNF 和 TrKB 表达。高范围的自愿锻炼表明，出现成瘾和吸毒行为的可能性增加。
To compare the effect of exercise and morphine on abstinence syndrome and hippocampal gene expression in rat model. Thirty adult male rats were exposed to voluntary wheel exercise (low, medium, high) for 28 days. The subjects entered Conditioned Place Preference (CPP) apparatus and experienced morphine (low, medium, high) CPP and followed by naloxone test. Correlation between exercise level, morphine injection, concurrent morphine administration and exercise with morphine CPP, BDNF and TrkB genes was determined. Rats were euthanized, decapitated and the hippocampus was removed. The expression of BDNF and TrkB genes were evaluated by real time PCR. Active rats ran an average of 839.18 m/d. A significant (P<0.001) correlation between exercise level, morphine injection, concurrent morphine administration and exercise with morphine CPP and BDNFand TrKB gene expressions was found. Voluntary exercise in different levels potentiates the brain rewarding system, CPP scale, and hippocampal BDNF and TrKB expressions. High range of voluntary exercise demonstrated an increase in the likelihood of developing addictive and drug-seeking behavior.
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影响因子：
2.7
作者：
Greenwood, Benjamin N.;Foley, Teresa E.;Le, Tony V.;Strong, Paul V.;Loughridge, Alice B.;Day, Heidi E. W.;Fleshner, Monika
通讯作者：
Fleshner, Monika
影响因子：
--
作者：
Lichtenstein, Mia Beck;Jensen, Tanja Tang
通讯作者：
Jensen, Tanja Tang
影响因子：
3.6
作者：
Mathes, WF;Kanarek, RB
通讯作者：
Kanarek, RB
影响因子：
2.7
作者：
Gobbo, OL;O'Mara, SM
通讯作者：
O'Mara, SM
影响因子：
2.7
作者：
O'Callaghan, Rachel M.;Ohle, Robert;Kelly, Aine M.
通讯作者：
Kelly, Aine M.