Effect of weight loss by a low-fat diet and a low-carbohydrate diet on peptide YY levels.
Effect of weight loss by a low-fat diet and a low-carbohydrate diet on peptide YY levels.
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DOI:
10.1038/ijo.2010.48
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发表时间:
2010-08
影响因子:
4.9
通讯作者:
Nestler, J. E.
中科院分区:
文献类型:
--
作者:
Essah, P. A.;Levy, J. R.;Sistrun, S. N.;Kelly, S. M.;Nestler, J. E.
To compare the effects of weight loss by an energy-restricted low-fat diet versus low-carbohydrate diet on serum peptide YY (PYY) levels. 8-week prospective study of 30 obese adults (mean age: 42.8 ± 2.0 years, mean BMI 35.5 ± 0.6 kg/m2). After 8 weeks, subjects on the low-carbohydrate diet lost substantially more weight than those on the low-fat diet (5.8 kg vs. 0.99 kg, p<0.001). Weight loss by either diet resulted in a 9% reduction in both mean fasting serum PYY levels (baseline: 103.5 ± 8.8 pg/ml, after weight loss: 94.1 ± 6.5 pg/ml, p<0.01) and postprandial AUC PYY (baseline: (20.5 ± 1.5) × 103 pg·hr−1ml−1, after weight loss: mean AUC PYY (18.8 ± 1.4) × 103 pg·hr−1ml−1 p<0.001). There was a trend towards lower levels of PYY with greater degrees of weight loss. Reduced PYY levels after weight loss by an energy-restricted low-fat or low-carbohydrate diet likely represents a compensatory response to maintain energy homeostasis and contributes to difficulty in weight loss during energy-restricted diets.
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