Simultaneous measurements of kinematics and fMRI: compatibility assessment and case report on recovery evaluation of one stroke patient.
Simultaneous measurements of kinematics and fMRI: compatibility assessment and case report on recovery evaluation of one stroke patient.
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DOI：
10.1186/1743-0003-7-49
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发表时间：
2010-09-23
影响因子：
5.1
通讯作者：
Pedrocchi A
中科院分区：
文献类型：
--
作者：
Casellato C;Ferrante S;Gandolla M;Volonterio N;Ferrigno G;Baselli G;Frattini T;Martegani A;Molteni F;Pedrocchi A
将实际执行的运动的特征与相关的皮质激活相关联可以提高功能磁共振成像(FMRI)数据解释的可靠性。这对于纵向评估神经科患者的运动恢复以及研究激活图和运动参数之间的详细相互作用是至关重要的。因此，我们探索了一种结合功能磁共振成像和光电运动捕捉系统的新装置，它提供了对所执行的运动任务的多参数量化。运动系统的摄像头安装在MR房间内，被动标记放置在受试者皮肤上，没有任何风险或负担。多功能的设置允许三维多段采集，包括记录可能的镜片移动，并且它保证了很高的会话间重复性。我们通过兼容性测试验证了集成设置的可靠性。然后，在一名健康志愿者身上测试了一种结合运动学记录的功能磁共振模块设计方案，该志愿者正在进行手指敲击和脚踝背-足底屈曲。通过对一例偏瘫患者进行踝关节后屈的康复治疗，初步评估了康复前后的临床适用性和远景。在所有会议中，将运动学数据集成到模型设计中的方法与标准分析进行了比较。对Phantom的收购展示了不折不扣的图像质量。健康的受试者使用运动学回归模型验证了协议的可行性和模型的可靠性。患者结果显示，当图像分析包括在回归模型中时，大脑激活图更加一致，除了刺激，运动学回归因子量化了实际执行的运动(运动时间和幅度)，证明了模型的显著改进。此外，在运动恢复评估方面，在康复一个月后，运动期间激活了更大的皮质区域，与通常与功能恢复相关的聚焦相反。事实上，运动学数据的可用性允许将这一更广泛的区域与更高的频率和更大的运动幅度相关联。运动学采集的结果是可靠和通用的，可以丰富fMRI图像信息，从而评估神经科患者的运动恢复，因为需要的运动和执行的运动可能会有很大的差异。
Correlating the features of the actual executed movement with the associated cortical activations can enhance the reliability of the functional Magnetic Resonance Imaging (fMRI) data interpretation. This is crucial for longitudinal evaluation of motor recovery in neurological patients and for investigating detailed mutual interactions between activation maps and movement parameters. Therefore, we have explored a new set-up combining fMRI with an optoelectronic motion capture system, which provides a multi-parameter quantification of the performed motor task. The cameras of the motion system were mounted inside the MR room and passive markers were placed on the subject skin, without any risk or encumbrance. The versatile set-up allows 3-dimensional multi-segment acquisitions including recording of possible mirror movements, and it guarantees a high inter-sessions repeatability. We demonstrated the integrated set-up reliability through compatibility tests. Then, an fMRI block-design protocol combined with kinematic recordings was tested on a healthy volunteer performing finger tapping and ankle dorsal- plantar-flexion. A preliminary assessment of clinical applicability and perspectives was carried out by pre- and post rehabilitation acquisitions on a hemiparetic patient performing ankle dorsal- plantar-flexion. For all sessions, the proposed method integrating kinematic data into the model design was compared with the standard analysis. Phantom acquisitions demonstrated the not-compromised image quality. Healthy subject sessions showed the protocols feasibility and the model reliability with the kinematic regressor. The patient results showed that brain activation maps were more consistent when the images analysis included in the regression model, besides the stimuli, the kinematic regressor quantifying the actual executed movement (movement timing and amplitude), proving a significant model improvement. Moreover, concerning motor recovery evaluation, after one rehabilitation month, a greater cortical area was activated during exercise, in contrast to the usual focalization associated with functional recovery. Indeed, the availability of kinematics data allows to correlate this wider area with a higher frequency and a larger amplitude of movement. The kinematic acquisitions resulted to be reliable and versatile to enrich the fMRI images information and therefore the evaluation of motor recovery in neurological patients where large differences between required and performed motion can be expected.
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影响因子：
8.3
作者：
Cramer, SC;Nelles, G;Rosen, BR
通讯作者：
Rosen, BR
影响因子：
2.5
作者：
Lutz, K;Koeneke, S;Jäncke, L
通讯作者：
Jäncke, L
影响因子：
4.8
作者：
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Phillips, Micheal D.
影响因子：
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作者：
Diciotti, Stefano;Gavazzi, Cinzia;Mascalchi, Mario
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Mascalchi, Mario
影响因子：
2
作者：
Ciccarelli, O;Toosy, AT;Thompson, AJ
通讯作者：
Thompson, AJ