Characterizing the dimensional structure of early-life adversity in the Adolescent Brain Cognitive Development (ABCD) Study.
Characterizing the dimensional structure of early-life adversity in the Adolescent Brain Cognitive Development (ABCD) Study.
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DOI：
10.1016/j.dcn.2023.101256
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发表时间：
2023-06
影响因子：
4.7
通讯作者：
Gee, Dylan G.
中科院分区：
文献类型：
--
作者：
Brieant, Alexis;Vannucci, Anna;Nakua, Hajer;Harris, Jenny;Lovell, Jack;Brundavanam, Divya;Tottenham, Nim;Gee, Dylan G.
早年的逆境对青年的神经发展和适应有着深远的影响；然而，逆境的经历是多种多样的，而且以复杂的方式相互关联，在发展研究中可能难以操作和组织。我们试图从美国青少年社区样本青少年大脑认知发展(ABCD)研究(N=7115)中表征共同发生的不良经历在一组青少年(9-10岁)中的潜在维度结构。我们确定了60个反映不良体验的环境和经验变量。探索性因素分析确定了早期生活逆境共同发生的10个稳健维度，对应于照顾者物质使用和生物照顾者分离、照顾者精神病理学、照顾者缺乏支持和社会经济劣势/社区缺乏安全等概念领域。这些维度与内在性问题、外部性问题、认知灵活性和抑制性控制有明显的关联。非度量多维尺度表征了10个已识别维度之间的定性相似性。研究结果支持一个代表早期逆境的非线性三维结构，包括“视角”、“环境不确定性”和“遗漏/委托行为”的连续梯度。我们的发现表明，在基线的ABCD样本中，早期生活逆境共同出现的不同维度，以及由此产生的维度可能对神经发育和青少年行为具有独特的影响。数据驱动的方法可以解释早期生活逆境(ELA)的异质性。在大量以人口为基础(即没有因逆境而丰富)的青年样本中，ELA可以减少到10个维度的共现。共同出现的ELA维度与心理健康和认知控制结果有不同的关联。在一个独立的复制样本中，共同出现的ELA维度预测了儿童的结局。非线性多维表示揭示了三个连续的ELA梯度。
Early-life adversity has profound consequences for youth neurodevelopment and adjustment; however, experiences of adversity are heterogeneous and interrelated in complex ways that can be difficult to operationalize and organize in developmental research. We sought to characterize the underlying dimensional structure of co-occurring adverse experiences among a subset of youth (ages 9–10) from the Adolescent Brain Cognitive Development (ABCD) Study (N = 7115), a community sample of youth in the United States. We identified 60 environmental and experiential variables that reflect adverse experiences. Exploratory factor analysis identified 10 robust dimensions of early-life adversity co-occurrence, corresponding to conceptual domains such as caregiver substance use and biological caregiver separation, caregiver psychopathology, caregiver lack of support, and socioeconomic disadvantage / neighborhood lack of safety. These dimensions demonstrated distinct associations with internalizing problems, externalizing problems, cognitive flexibility, and inhibitory control. Non-metric multidimensional scaling characterized qualitative similarity among the 10 identified dimensions. Results supported a nonlinear three-dimensional structure representing early-life adversity, including continuous gradients of “perspective”, “environmental uncertainty”, and “acts of omission/commission”. Our findings suggest that there are distinct dimensions of early-life adversity co-occurrence in the ABCD sample at baseline, and the resulting dimensions may have unique implications for neurodevelopment and youth behavior. Data-driven methods can elucidate heterogeneity in early-life adversity (ELA). ELA could be reduced to 10 dimensions of co-occurrence in a large population-based (i.e., not enriched for adversity) sample of youth. ELA dimensions of co-occurrence were differentially associated with mental health and cognitive control outcomes. ELA dimensions of co-occurrence predicted child outcomes in an independent replication sample. Nonlinear multidimensional representation revealed three continuous ELA gradients.
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影响因子：
4.7
作者：
Barch DM;Albaugh MD;Baskin-Sommers A;Bryant BE;Clark DB;Dick AS;Feczko E;Foxe JJ;Gee DG;Giedd J;Glantz MD;Hudziak JJ;Karcher NR;LeBlanc K;Maddox M;McGlade EC;Mulford C;Nagel BJ;Neigh G;Palmer CE;Potter AS;Sher KJ;Tapert SF;Thompson WK;Xie L
通讯作者：
Xie L
影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup
影响因子：
--
作者：
通讯作者：
--
影响因子：
5
作者：
Hoffman, Elizabeth A.;Clark, Duncan B.;Dowling, Gayathri J.
通讯作者：
Dowling, Gayathri J.
DOI：
10.1073/pnas.1121246109
发表时间：
2012-10-16
影响因子：
11.1
作者：
Hostinar, Camelia E.;Stellern, Sarah A.;Gunnar, Megan R.
通讯作者：
Gunnar, Megan R.