Serum soluble B7-H4 is a prognostic marker for patients with non-metastatic clear cell renal cell carcinoma.
Serum soluble B7-H4 is a prognostic marker for patients with non-metastatic clear cell renal cell carcinoma.
复制标题
DOI：
10.1371/journal.pone.0199719
复制
发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Kume H
中科院分区：
文献类型：
--
作者：
Azuma T;Sato Y;Ohno T;Azuma M;Kume H
B7-H4是免疫调节配体B7家族的成员，被认为是免疫应答的负调节剂。我们研究了血清可溶性B7-H4在非转移性肾透明细胞癌患者中的临床意义。我们分析了2008年至2013年期间在东京都立多摩医疗中心诊断为非转移性透明细胞肾癌的108例患者。我们使用酶联免疫吸附试验（ELISA）测定血清可溶性B7-H4水平，并评估外周血中性粒细胞计数和sB 7-H4之间的相关性，以及可溶性B7-H4作为肾透明细胞癌预后生物标志物的效用。采用考克斯比例风险回归模型评估PFS和OS与可溶性B7-H4水平的关系。我们在56%的非转移性肾透明细胞癌患者的血清中检测到高水平的可溶性B7-H4，而在健康供体中仅检测到10%。可溶性B7-H4水平升高与外周血中性粒细胞计数升高相关。多因素分析显示，血清可溶性B7-H4水平升高是PFS和OS的独立预后因素。我们的数据表明，血清可溶性B7-H4与外周血中性粒细胞计数之间的关系，血清可溶性B7-H4的表达是预测非转移性肾透明细胞癌患者预后的有用工具。
B7-H4 is a member of the B7 family of immune-regulatory ligands and is considered to be a negative regulator of the immune response. We investigated the clinical significance of serum soluble B7-H4 in patients with non-metastatic clear cell renal cell carcinoma. We analyzed 108 patients in whom non-metastatic clear cell renal cancer was diagnosed at Tokyo Metropolitan Tama Medical Center between 2008 and 2013. We measured the serum soluble B7-H4 level using the Enzyme-Linked ImmunoSorbent Assay (ELISA) and evaluated the association between the peripheral blood neutrophil count and sB7-H4 as well as the utility of soluble B7-H4 as a prognostic biomarker for clear cell renal cancer. The Cox proportional hazards regression model was used to assess the PFS and OS with the soluble B7-H4 level. We detected high levels of soluble B7-H4 in the sera of 56% of patients with non-metastatic clear cell renal cell carcinoma versus only 10% of healthy donors. Elevated soluble B7-H4 levels were associated with changes in an elevated peripheral blood neutrophil count. The increase of soluble B7-H4 also was significantly associated with poor PFS and OS. Multivariate analysis showed that the elevation of the soluble B7-H4 level was an independent prognostic factor for PFS and OS. Our data suggest that the association between serum soluble B7-H4 and peripheral blood neutrophil count, as well as the evaluation of serum soluble B7-H4 expression is a useful tool for predicting the prognosis of patients with non-metastatic clear cell renal cell carcinoma.
登录
查看更多内容
影响因子：
15.8
作者：
Azuma T;Zhu G;Xu H;Rietz AC;Drake CG;Matteson EL;Chen L
通讯作者：
Chen L
影响因子：
2.5
作者：
Walsh, SR;Cook, EJ;Keeling, NJ
通讯作者：
Keeling, NJ
影响因子：
--
作者：
Dong Q;Ma X
通讯作者：
Ma X
影响因子：
2.6
作者：
Dong, Hui;Wang, Cheng;Zhang, Chen-Yu
通讯作者：
Zhang, Chen-Yu
影响因子：
5.8
作者：
Cho, HanByoul;Hur, Hye Won;Lee, Kook
通讯作者：
Lee, Kook