Daily stressors, past depression, and metabolic responses to high-fat meals: a novel path to obesity.
Daily stressors, past depression, and metabolic responses to high-fat meals: a novel path to obesity.
复制标题
DOI：
10.1016/j.biopsych.2014.05.018
复制
发表时间：
2015-04-01
影响因子：
10.6
通讯作者：
Belury, Martha A.
中科院分区：
文献类型：
--
作者：
Kiecolt-Glaser, Janice K.;Habash, Diane L.;Fagundes, Christopher P.;Andridge, Rebecca;Peng, Juan;Malarkey, William B.;Belury, Martha A.
抑郁和压力会导致肥胖。本研究探讨了日常压力源和重度抑郁症（MDD）病史对高脂饮食引起的肥胖相关代谢反应的影响。这项双盲、随机交叉研究包括对两次高脂餐前后的静息能量消耗（REE）、脂肪和碳水化合物氧化、甘油三酯、皮质醇、胰岛素和葡萄糖进行系列评估。在两个独立的9.5小时的住院期间，58名健康女性（38名乳腺癌幸存者和20名人口统计学相似的对照组），平均年龄53.1岁，接受高饱和脂肪餐或高油酸向日葵油餐。前一天的压力源进行了评估，每日库存的压力事件和MDD病史的结构化临床访谈DSM-IV。更多的压力源与较低的餐后REE（P= 0.008），较低的脂肪氧化（P= 0.04）和较高的胰岛素（P= 0.01）相关，对皮质醇（P= 0.25）和葡萄糖（P= 0.33）无显著影响。有抑郁症病史的女性皮质醇水平较高（P= 0.008），脂肪氧化水平较高（P= 0.004），对REE（P= 0.26）、胰岛素（P= 0.25）和葡萄糖（P= 0.38）无显著影响。有抑郁症史的妇女，也有更多的前一天的压力，有更高的峰值甘油三酯反应比其他参与者（P= 0.01）。两餐之间的唯一差异是与饱和脂肪相比，向日葵籽油后的餐后血糖较高（P=.03）。前一天压力源和无压力源之间的累积6小时差异转化为104千卡，这一差异可能增加近11磅/年。这些发现说明了压力和抑郁如何改变对高脂肪食物的代谢反应，从而促进肥胖。
Depression and stress promote obesity. This study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on obesity-related metabolic responses to high-fat meals. This double-blind, randomized crossover study included serial assessments of resting energy expenditure (REE), fat and carbohydrate oxidation, triglycerides, cortisol, insulin and glucose before and after two high-fat meals. During two separate 9.5 hour admissions, 58 healthy women (38 breast cancer survivors and 20 demographically-similar controls), mean age 53.1 years, received either a high saturated fat meal or a high oleic sunflower oil meal. Prior day stressors were assessed by the Daily Inventory of Stressful Events and MDD history by the Structured Clinical Interview for DSM-IV. Greater numbers of stressors were associated with lower post-meal REE (P=.008), lower fat oxidation (P=.04), and higher insulin (P=.01), with nonsignificant effects for cortisol (P=.25) and glucose (P=.33). Women with prior MDD had higher cortisol (P=.008), and higher fat oxidation (P=.004), without significant effects for REE (P=.26), insulin (P=.25), and glucose (P=.38). Women with a depression history who also had more prior day stressors had a higher peak triglyceride response than other participants (P=.01). The only difference between meals was higher postprandial glucose following sunflower oil compared to saturated fat (P=.03). The cumulative 6-hour difference between one prior day stressor and no stressors translates into 104 kcal, a difference that could add almost 11 pounds/year. These findings illustrate how stress and depression alter metabolic responses to high-fat meals in ways that promote obesity.
登录
查看更多内容
影响因子：
--
作者：
Allman-Farinelli, MA;Gomes, K;Petocz, P
通讯作者：
Petocz, P
影响因子：
5.9
作者：
Carney, Robert M.;Freedland, Kenneth E.
通讯作者：
Freedland, Kenneth E.
影响因子：
4.2
作者：
Blanton, Cynthia A.;Moshfegh, Alanna J.;Kretsch, Mary J.
通讯作者：
Kretsch, Mary J.
影响因子：
37.8
作者：
Boquist, S;Ruotolo, G;Hamsten, A
通讯作者：
Hamsten, A
影响因子：
2.6
作者：
Campbell, K. L.;Lane, K.;McKenzie, D. C.
通讯作者：
McKenzie, D. C.