Seeking behavior, place conditioning, and resistance to conditioned suppression of feeding in rats intermittently exposed to palatable food.
Seeking behavior, place conditioning, and resistance to conditioned suppression of feeding in rats intermittently exposed to palatable food.
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DOI：
10.1037/bne0000042
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发表时间：
2015-04
影响因子：
1.9
通讯作者：
Cottone, Pietro
中科院分区：
文献类型：
--
作者：
Velazquez-Sanchez, Clara;Santos, Jeffrey W.;Smith, Karen L.;Ferragud, Antonio;Sabino, Valentina;Cottone, Pietro
关键词：
暴饮暴食症的特征是在短时间内过度食用非常可口的食物，并伴有对饮食的失控。大量证据支持将暴食症视为成瘾样疾病。在这项研究中，我们想确定大鼠是否经历了一个操作性的暴食样进食程序可能发展适应不良形式的条件喂养行为。为此目的，我们训练雄性大鼠每天自我给予含糖的高适口性饮食（适口大鼠）或普通饲料（普通大鼠）1小时。在适口性食物摄入量增加和稳定后，我们在i）条件性位置偏好测试、ii）二阶强化时间表和iii）线索诱导的摄食抑制测试中测试了Chow和Palatable大鼠。在条件性位置偏好任务中，与食物对照组相比，适口大鼠在先前与适口食物配对的隔室中花费了显著更多的时间。此外，在强化任务的二级时间表，适口大鼠表现出主动杠杆反应4- 6倍高于饲料对照组大鼠。最后，在线索诱导的抑制喂养试验中，虽然饮食控制受试者减少了32%的条件惩罚的存在下，适口大鼠坚持响应，尽管厌恶的线索。这些结果进一步表征了这种暴食样进食的动物模型，并为高度可口的食物的成瘾特性提供了额外的证据。
Binge eating disorder is characterized by excessive consumption of highly palatable food within short periods of time accompanied by loss of control over eating. Extensive evidence provides support for the consideration of binge eating disorder as an addiction-like disorder. In this study, we wanted to determine whether rats undergoing an operant binge-like eating procedure could develop maladaptive forms of conditioned feeding behaviors. For this purpose, we trained male rats to self-administer either a sugary, highly palatable diet (Palatable rats) or a chow diet (Chow rats) for 1 hour a day. Following escalation and stabilization of palatable food intake, we tested Chow and Palatable rats in i) a conditioned place preference test, ii) a second-order schedule of reinforcement, and iii) a cue-induced suppression of feeding test. In the conditioned place preference task, Palatable rats spent significantly more time in the compartment that was previously paired with the palatable food, compared to Chow controls. Furthermore, in the second order schedule of reinforcement task, Palatable rats exhibited active lever responding 4- to 6-fold higher than Chow control rats. Finally, in the cue-induced suppression of feeding test, while Chow control subjects reduced responding by 32% in the presence of the conditioned punishment, Palatable rats persevered in responding despite the aversive cue. These results further characterize this animal model of binge-like eating and provide additional evidence for the addictive properties of highly palatable food.
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影响因子：
3.6
作者：
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作者：
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通讯作者：
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