Risk/reward decision-making in schizophrenia: a preliminary examination of the influence of tobacco smoking and relationship to Wisconsin Card Sorting Task performance.
Risk/reward decision-making in schizophrenia: a preliminary examination of the influence of tobacco smoking and relationship to Wisconsin Card Sorting Task performance.
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DOI：
10.1016/j.schres.2009.01.012
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发表时间：
2009-05
影响因子：
4.5
通讯作者：
Potenza, Marc N.
中科院分区：
文献类型：
--
作者：
Yip, Sarah W.;Sacco, Kristi A.;George, Tony P.;Potenza, Marc N.
关键词：
精神分裂症患者在认知功能方面存在缺陷，威斯康星卡片分类任务（WCST）等神经认知任务中的缺陷就证明了这一点。对精神分裂症患者风险/回报决策的研究结果不一，且很少有研究系统地考察这些领域之间的关系以及它们与临床因素的关系。
32名患有精神分裂症的吸烟者、10名患有精神分裂症的非吸烟者、9名无精神疾病的非吸烟者和10名无精神疾病的吸烟者接受了爱荷华赌博任务（IGT）和WCST的计算机化版本测试。吸烟者在指定的休息时间可以随意吸烟，以防止戒断反应。
精神分裂症患者在IGT和WCST两项任务上的表现都明显比无精神疾病的对照组差，而且这些任务的表现跨受试者群体具有显著相关性。在患有精神分裂症的女性中，吸烟者在IGT上的表现明显优于非吸烟者。
精神分裂症患者在IGT上的表现比对照组差，这表明其风险/回报决策能力受损。IGT和WCST表现之间的相关性表明任务表现背后存在一个共同因素，比如定势转换或坚持性方面的缺陷。需要进一步的研究来确定吸烟与精神分裂症患者IGT表现之间的关系。
Individuals with schizophrenia show deficits in cognitive functioning, as evidenced by deficits on neurocognitive tasks such as the Wisconsin Card Sorting Task (WCST). Studies of risk/reward decision-making in individuals with schizophrenia have yielded mixed results, and few studies have examined systematically the relationship between these domains and their relationship with clinical factors. Thirty-two smokers with schizophrenia, ten non-smokers with schizophrenia, nine non-psychiatric non-smokers and ten non-psychiatric smokers were administered computerized versions of the Iowa Gambling Task (IGT) and the WCST. Smokers were allowed to smoke ad libitum during designated breaks in order to prevent deprivation. Subjects with schizophrenia performed significantly worse than non-psychiatric controls on both the IGT and the WCST, and performance on these tasks was significantly correlated across subject groups. Among women with schizophrenia, smokers performed significantly better than non-smokers on the IGT. Individuals with schizophrenia performed worse than controls on the IGT, suggesting impairments in risk/reward decision-making. Correlations between IGT and WCST performance suggest a shared element underlying task performance, such as a deficit in set-shifting or perseverance. Further research is needed to establish the relationship between cigarette smoking and IGT performance in schizophrenia.
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作者：
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通讯作者：
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DOI：
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