The impact of PTSD treatment on the cortisol awakening response.
The impact of PTSD treatment on the cortisol awakening response.
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DOI：
10.1002/da.22298
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发表时间：
2014-10
影响因子：
7.4
通讯作者：
Delahanty, Douglas L.
中科院分区：
文献类型：
--
作者：
Pacella, Maria L.;Feeny, Norah;Zoellner, Lori;Delahanty, Douglas L.
Posttraumatic stress disorder (PTSD) is associated with abnormal functioning of the hypothalamic-pituitary-adrenal (HPA) axis; however, limited research has examined whether cortisol levels change following successful PTSD treatment. The current study examined the impact of successful PTSD treatment on the cortisol awakening response (CAR). Twenty-nine adults participating in a treatment trial for chronic PTSD provided saliva samples (upon waking, and 30, 45, and 60-min post-waking) before and after receiving either prolonged exposure therapy or sertraline. PTSD responder status (i.e., loss or retention of a PTSD diagnosis) served as the predictor variable. Outcome measures included area under the curve with respect to ground and increase, reflecting total cortisol output and HPA axis reactivity, respectively. A series of hierarchical regressions revealed no significant main effects of PTSD responder status for either CAR outcome. However, a significant gender by treatment response interaction for cortisol reactivity revealed that female treatment non-responders displayed higher cortisol reactivity following treatment than female responders, whereas cortisol reactivity did not change pre- to post-treatment for male responders. Findings remained after controlling for age, trauma history, baseline medication status, baseline PTSD, and baseline depressive symptoms. Loss of a PTSD diagnosis may contribute to decreased cortisol reactivity in females. Neuroendocrine changes following treatment may emerge only for specific subgroups, highlighting the importance of exploring treatment moderators.
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影响因子：
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通讯作者：
Goodey, E
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Inslicht, Sabra S.;Otte, Christian;McCaslin, Shannon E.;Apfel, Brigitte A.;Henn-Haase, Clare;Metzler, Thomas;Yehuda, Rachel;Neylan, Thomas C.;Marmar, Charles R.
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作者：
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