Adiponectin is inversely associated with intramyocellular and intrahepatic lipids in obese premenopausal women.
Adiponectin is inversely associated with intramyocellular and intrahepatic lipids in obese premenopausal women.
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DOI：
10.1038/oby.2010.296
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Miller KK
中科院分区：
文献类型：
--
作者：
Bredella MA;Torriani M;Ghomi RH;Thomas BJ;Brick DJ;Gerweck AV;Harrington LM;Miller KK
脂联素是由脂肪细胞分泌的一种脂肪因子，对糖和脂代谢具有有益的作用，并已被发现通过降低肥胖小鼠肌肉和肝脏中的甘油三酯含量来改善胰岛素抵抗。脂联素有几种异构体，高分子量（HMW）形式与胰岛素增敏作用关系最密切。骨骼肌（肌内脂质，IMCL）和肝脏（肝内脂质，IHL）中的脂肪含量可以使用质子磁共振波谱（1H-MRS）进行无创定量。本研究的目的是评估高分子量脂联素与葡萄糖稳态、IMCL和IHL指标之间的关系，并确定脂联素水平的预测因子。我们研究了66名绝经前妇女（平均BMI 31.0 ± 6.6 kg/m2），接受小腿肌肉和肝脏1H-MRS检查IMCL和IHL，腹部计算机断层扫描（CT）检查腹部脂肪库，双能X线吸收测定法（DXA）检查脂肪和瘦体重评估，HMW和总脂联素，空腹血脂谱和口服葡萄糖耐量试验（胰岛素抵抗的稳态模型评估（HOMAIR）、葡萄糖和胰岛素曲线下面积）。高分子量脂联素与胰岛素抵抗、IMCL和IHL指标呈强负相关，独立于内脏脂肪组织（VAT）和全身脂肪。IHL是脂联素的最强预测因子，脂联素是HOMAIR的预测因子。我们的研究表明，在绝经前肥胖妇女中，高分子量脂联素与IMCL和IHL含量呈负相关。这表明脂联素通过降低骨骼肌和肝脏中的细胞内甘油三酯含量对肥胖症的胰岛素敏感性产生积极影响;我们的结果也可能反映胰岛素对脂联素的影响。
Adiponectin, an adipokine secreted by adipocytes, exerts beneficial effects on glucose and lipid metabolism and has been found to improve insulin resistance by decreasing triglyceride content in muscle and liver in obese mice. Adiponectin is found in several isoforms and the high-molecular weight (HMW) form has been linked most strongly to the insulin-sensitizing effects. Fat content in skeletal muscle (intramyocellular lipids, IMCL) and liver (intrahepatic lipids, IHL) can be quantified noninvasively using proton magnetic resonance spectroscopy (1H-MRS). The purpose of our study was to assess the relationship between HMW adiponectin and measures of glucose homeostasis, IMCL and IHL, and to determine predictors of adiponectin levels. We studied 66 premenopausal women (mean BMI 31.0 ± 6.6 kg/m2) who underwent 1H-MRS of calf muscles and liver for IMCL and IHL, computed tomography (CT) of the abdomen for abdominal fat depots, dual-energy X-ray absorptiometry (DXA) for fat and lean mass assessments, HMW and total adiponectin, fasting lipid profile and an oral glucose tolerance test (homeostasis model assessment of insulin resistance (HOMAIR), glucose and insulin area under the curve). There were strong inverse associations between HMW adiponectin and measures of insulin resistance, IMCL and IHL, independent of visceral adipose tissue (VAT) and total body fat. IHL was the strongest predictor of adiponectin and adiponectin was a predictor of HOMAIR. Our study showed that in premenopausal obese women HMW adiponectin is inversely associated with IMCL and IHL content. This suggests that adiponectin exerts positive effects on insulin sensitivity in obesity by decreasing intracellular triglyceride content in skeletal muscle and liver; it is also possible that our results reflect effects of insulin on adiponectin.
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影响因子：
16.2
作者：
Blueher, Matthias;Fasshauer, Mathias;Mantzoros, Christos S.
通讯作者：
Mantzoros, Christos S.
影响因子：
7.1
作者：
BORKAN, GA;GERZOF, SG;SILBERT, JE
通讯作者：
SILBERT, JE
影响因子：
5.8
作者：
Frederiksen, L.;Nielsen, T. L.;Andersen, M.
通讯作者：
Andersen, M.
影响因子：
7.1
作者：
Koska, Juraj;Stefan, Norbert;Bunt, Joy C.
通讯作者：
Bunt, Joy C.
影响因子：
1.3
作者：
Bredella, Miriam A.;Ghomi, Reza Hosseini;Torriani, Martin
通讯作者：
Torriani, Martin