Intrinsic mechanisms of neuronal axon regeneration.
Intrinsic mechanisms of neuronal axon regeneration.
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DOI：
10.1038/s41583-018-0001-8
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Cavalli V
中科院分区：
文献类型：
--
作者：
Mahar M;Cavalli V
中枢神经系统损伤后的永久性残疾是由于受损轴突无法再生和重建与其原始目标的功能连接。相比之下，周围神经损伤之后是强大的再生，这可以导致感觉和运动功能的恢复。这种再生反应需要在受损神经元中诱导广泛的转录和表观遗传变化。近年来，在理解外周轴突损伤如何通过转录因子、表观遗传修饰剂以及在较小程度上microRNA的协调作用来引起这些广泛的变化方面取得了相当大的进展。尽管这些机制之间的相互作用仍存在许多问题，但这些新发现为协调基因表达和染色质重塑在神经元对损伤的反应中的关键作用提供了重要见解。
Permanent disabilities following CNS injuries result from the failure of injured axons to regenerate and rebuild functional connections with their original targets. By contrast, injury to peripheral nerves is followed by robust regeneration, which can lead to recovery of sensory and motor functions. This regenerative response requires the induction of widespread transcriptional and epigenetic changes in injured neurons. Considerable progress has been made in recent years in understanding how peripheral axon injury elicits these widespread changes through the coordinated actions of transcription factors, epigenetic modifiers and, to a lesser extent, microRNAs. Although many questions remain about the interplay between these mechanisms, these new findings provide important insights into the pivotal role of coordinated gene expression and chromatin remodelling in the neuronal response to injury.
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