Immune and inflammatory mechanisms of abdominal aortic aneurysm.

Immune and inflammatory mechanisms of abdominal aortic aneurysm.
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腹主动脉瘤的免疫和炎症机制。

DOI:
10.3389/fimmu.2022.989933
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发表时间:
2022
影响因子:
7.3
通讯作者:
Koltsova, Ekaterina K.
Koltsova, Ekaterina K.
中科院分区:
医学2区
文献类型:
--
作者:
Marquez-Sanchez, Ana Cristina;Koltsova, Ekaterina K.

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腹主动脉瘤(AAA)是一种危及生命的心血管疾病。 AAA 发展过程中免疫介导的浸润和主动脉壁破坏在该疾病的发病机制中发挥着重要作用。虽然在 AAA 中发现了多种免疫细胞,但它们的激活和功能机制仍远未了解。更好地了解 AAA 中异常免疫细胞激活的调节机制对于开发新的预防和治疗方法至关重要。在这篇综述中,我们总结了目前关于免疫细胞在 AAA 中的作用的知识,并讨论了如何在这种疾病中调节致病性免疫细胞的激活。
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-mediated infiltration and a destruction of the aortic wall during AAA development plays significant role in the pathogenesis of this disease. While various immune cells had been found in AAA, the mechanisms of their activation and function are still far from being understood. A better understanding of mechanisms regulating the development of aberrant immune cell activation in AAA is essential for the development of novel preventive and therapeutic approaches. In this review we summarize current knowledge about the role of immune cells in AAA and discuss how pathogenic immune cell activation is regulated in this disease.
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