Sympathetic modulation of mechanoreceptor sensitivity in frog skin.

Sympathetic modulation of mechanoreceptor sensitivity in frog skin.
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青蛙皮肤机械感受器敏感性的交感调节。

DOI:
10.1113/jphysiol.1981.sp013563
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发表时间:
1981
期刊:
The Journal of physiology
影响因子:
--
通讯作者:
Roberts,WJ
Roberts,WJ
中科院分区:
--
文献类型:
--
作者:
Calof,AL;Jones,RB;Roberts,WJ

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1.研究了交感神经对机械感受器机械敏感性的影响。2.在电刺激交感神经干的过程中,用重复机械刺激的阈值强度测试功能识别的单位。3.交感神经活动增加了三类传入的敏感性:缓慢适应压缩感受器、缓慢适应卒中感受器和快速适应卒中感受器。在第四类中,敏感度降低,迅速适应压缩感受器。4.几种可能的交感神经影响模式的初步测试表明,血流变化、探针-皮肤偶联的变化和组织顺应性的变化不能解释所观察到的感受器敏感性的变化。皮肤粘液腺分泌的Na+和Cl-离子可能是快速适应压力感受器敏感性降低的原因之一。直接神经递质对受体的作用,这可能是交感神经作用的机制,还没有得到测试。5.数据表明,皮肤敏感性发生系统性变化,交感传出活动略有变化。对这些交感神经效应的可能机制进行了讨论。
1. Sympathetic effects on the mechanical sensitivity of frogcutaneous mechanoreceptors were examined in vivo. 2. Functionallyidentified units were tested with repetitive mechanical stimuli ofthreshold intensity during electrical stimulation of the sympathetictrunk. 3. Sympathetic activity resulted in increased sensitivity forthree classes of afferents; slowly adapting compression receptors,slowly adapting stroke receptors, and rapidly adapting strokereceptors. Decreased sensitivity was produced in the fourth class,rapidly adapting compression receptors. 4. Preliminary tets of severalpossible modes of sympathetic influence indicated that blood flowchanges, changes in probe‐skin coupling and changes in tissuecompliance could not account for the observed changes in receptorsensitivity. Na+ and Cl‐ ions, secreted by cutaneous mucous glandswere found to be possible contributors to the decreased sensitivity ofrapidly adapting compression receptors. Direct neurotransmitter actionon the receptors, a likely mechanism of sympathetic action, was nottested. 5. The data indicate that systematic changes in cutaneoussensibility occur with modest changes in sympathetic efferentactivity. Possible mechanisms of these sympathetic effects arediscussed.
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