Rapid assessment of Opisthorchis viverrini IgG antibody in serum: A potential diagnostic biomarker to predict risk of cholangiocarcinoma in regions endemic for opisthorchiasis.
Rapid assessment of Opisthorchis viverrini IgG antibody in serum: A potential diagnostic biomarker to predict risk of cholangiocarcinoma in regions endemic for opisthorchiasis.
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快速评估血清中猪瘟蛇胸腺IgG抗体：预测蛇胸腺病流行地区胆管癌风险的潜在诊断生物标志物。
DOI：
10.1016/j.ijid.2021.12.347
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发表时间：
2022-03
影响因子：
8.4
通讯作者：
Maleewong, Wanchai
中科院分区：
文献类型：
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作者：
Rodpai, Rutchanee;Luvira, Vor;Sadaow, Lakkhana;Sukeepaisarnjaroen, Wattana;Kitkhuandee, Amnat;Paonariang, Krisada;Sanpool, Oranuch;Ittiprasert, Wannaporn;Mann, Victoria H.;Intapan, Pewpan M.;Brindley, Paul J.;Maleewong, Wanchai
关键词：
后睾吸虫病是由感染后睾吸虫属的鱼传播肝吸虫引起的。后睾吸虫病经常导致胆道慢性炎症，被国际癌症研究机构列为1组生物致癌物：胆管癌（CCA）的确定风险。采用快速免疫层析法（ICT）检测了CCA患者血清中抗猫颈后睾吸虫IgG和IgG 4亚类抗体。以O.灵猫成虫ICT检测结果显示，在36例CCA患者中，IgG抗体阳性22例（61.1%），IgG 4抗体阳性15例（41.6%）（P > 0.05）。我们的研究还包括其他癌症和肝硬化组，其中IgG ICT和IgG 4 ICT试剂盒分别为27.7%（13/47）和25.5%（12/47）（P > 0.05）。在20名健康参与者的对照组中，总IgG ICT和IgG 4 ICT均未产生阳性结果。CCA组与其他恶性肿瘤组及肝硬化组比较，ICT检测总IgG阳性率差异有统计学意义（P < 0.05）。相比之下，这些组之间在IgG 4抗体的ICT方面没有明显的显著差异。CCA组抗-O阳性的可能性是对照组的6.53倍。灵猫IgG抗体阳性率（OR 6.53，P < 0.001），抗O.灵猫IgG 4抗体阳性率（OR 3.27，P = 0.010）高于非CCA组。这一信息对于开发一种诊断性生物标志物来预测O。灵猫感染相关的CCA。
Opisthorchiasis is caused by an infection with fish-borne liver flukes of the genus Opisthorchis. Opisthorchiasis frequently leads to chronic inflammation in the biliary tract and is classified as a group 1 biological carcinogen by the International Agency for Research on Cancer: a definitive risk for cholangiocarcinoma (CCA). We used the rapid immunochromatographic test (ICT) to detect anti-Opisthorchis viverrini IgG and IgG4 subclass antibodies in sera of patients with CCA. The ICT kits were developed based on soluble antigens excreted and secreted by O. viverrini adult worms. ICT indicated sera was positive for IgG and IgG4 antibodies, respectively, in 22 (61.1%) and 15 (41.6%) participants of the 36 study participants diagnosed with CCA (P > 0.05). Our study also included groups with other cancers and with liver cirrhosis, where the IgG ICT and IgG4 ICT kits were 27.7% (13/47) and 25.5% (12/47) positive, respectively (P > 0.05). Neither total the IgG ICT nor the IgG4 ICT yielded positive results in a control group of 20 healthy participants. Moreover, the percentage positivity rate using the ICT for total IgG between the CCA group and the other cancers and liver cirrhosis group was significantly different (P < 0.05). By contrast, no significant difference between these groups was apparent in the ICT for IgG4 antibody. The CCA group was 6.53 times more likely to have positive anti–O. viverrini IgG antibody (odds ratio 6.53, P < 0.001) and 3.27 times more likely to have positive anti–O. viverrini IgG4 antibody (odds ratio 3.27, P = 0.010) than the non-CCA group. This information is of potential value for the development of a diagnostic biomarker to predict risk for O. viverrini infection-associated CCA.
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DOI：
10.1038/s41572-021-00300-2
发表时间：
2021-09-09
期刊：
Nature reviews. Disease primers
影响因子：
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作者：
通讯作者：
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影响因子：
2.3
作者：
Titapun A;Techasen A;Sa-Ngiamwibool P;Sithithaworn P;Luvira V;Srisuk T;Jareanrat A;Dokduang H;Loilome W;Thinkhamrop B;Khuntikeo N
通讯作者：
Khuntikeo N
影响因子：
65.1
作者：
Banales, Jesus M.;Cardinale, Vincenzo;Alvaro, Domenico
通讯作者：
Alvaro, Domenico
影响因子：
3.8
作者：
Khuntikeo N;Chamadol N;Yongvanit P;Loilome W;Namwat N;Sithithaworn P;Andrews RH;Petney TN;Promthet S;Thinkhamrop K;Tawarungruang C;Thinkhamrop B;CASCAP investigators
通讯作者：
CASCAP investigators
DOI：
10.1038/nrgastro.2011.131
发表时间：
2011-08-02
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
通讯作者：
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