Patterning mechanisms of branched organs.

Patterning mechanisms of branched organs.
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DOI:
10.1126/science.1162783
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发表时间:
2008-12-05
期刊:
影响因子:
56.9
通讯作者:
Werb, Zena
Werb, Zena
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Lu, Pengfei;Werb, Zena

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分支形态发生是后生动物成功所必需的最早事件之一。通过分支并形成细胞或组织延伸,细胞可以最大化其表面积并克服器官尺寸造成的空间限制。在过去的十年中,在理解各种无脊椎动物和脊椎动物器官系统的分支机制方面取得了巨大进展。尽管它们的起源、形态和功能不同,但不同的细胞和组织类型使用一组非常保守的工具来进行分支形态发生。最近的研究对不同器官中分支结构形成的分子守恒的基础提供了重要的启示。
Branching morphogenesis is one of the earliest events essential for the success of metazoans. By branching out and forming cellular or tissue extensions, cells can maximize their surface area and overcome space constraints posed by organ size. Over the past decade, tremendous progress has been made toward understanding the branching mechanisms of various invertebrate and vertebrate organ systems. Despite their distinct origins, morphologies and functions, different cell and tissue types use a remarkably conserved set of tools to undergo branching morphogenesis. Recent studies have shed important light on the basis of molecular conservation in the formation of branched structures in diverse organs.
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