Patterning mechanisms of branched organs.
Patterning mechanisms of branched organs.
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DOI:
10.1126/science.1162783
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发表时间:
2008-12-05
期刊:
影响因子:
56.9
通讯作者:
Werb, Zena
中科院分区:
文献类型:
--
作者:
Lu, Pengfei;Werb, Zena
Branching morphogenesis is one of the earliest events essential for the success of metazoans. By branching out and forming cellular or tissue extensions, cells can maximize their surface area and overcome space constraints posed by organ size. Over the past decade, tremendous progress has been made toward understanding the branching mechanisms of various invertebrate and vertebrate organ systems. Despite their distinct origins, morphologies and functions, different cell and tissue types use a remarkably conserved set of tools to undergo branching morphogenesis. Recent studies have shed important light on the basis of molecular conservation in the formation of branched structures in diverse organs.
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