Expression levels of UL16 binding protein 1 and natural killer group 2 member D affect overall survival in patients with gastric cancer following gastrectomy.
Expression levels of UL16 binding protein 1 and natural killer group 2 member D affect overall survival in patients with gastric cancer following gastrectomy.
复制标题
DOI：
10.3892/ol.2017.7354
复制
发表时间：
2018-01
期刊：
影响因子：
2.9
通讯作者：
Nagano H
中科院分区：
文献类型：
--
作者：
Kamei R;Yoshimura K;Yoshino S;Inoue M;Asao T;Fuse M;Wada S;Kuramasu A;Furuya-Kondo T;Oga A;Iizuka N;Suzuki N;Maeda N;Watanabe Y;Matsukuma S;Iida M;Takeda S;Ueno T;Yamamoto N;Fukagawa T;Katai H;Sasaki H;Hazama S;Oka M;Nagano H
肿瘤细胞表面表达的 UL16 结合蛋白 1 (ULBP1) 与自然杀伤 (NK)、分化簇 (CD)8+ T 细胞和 γ δ T 细胞上呈现的自然杀伤组 2 成员 D (NKG2D) 受体结合。然而，ULBP1 和 NKG2D 表达以及相关免疫反应在胃癌中的作用尚不清楚。本研究调查了胃癌患者中 ULBP1 和 NKG2D 表达与临床结果之间的关联。对 2004 年至 2008 年接受手术的 98 名患者的人胃癌细胞系和胃癌组织中的 ULBP1 和 NKG2D 表达水平进行了检查。MKN-74 细胞表达 ULBP1 和 ULBP2、-5 或 -6。 T 细胞和 NK 细胞激活后，NKG2D 的表达水平较高。 NKG2D表达阳性的组织切片中，6例患者CD8和CD56呈阳性。在所有组织中，表达 NKG2D 的细胞通常是 aCD8+ T 细胞。与肿瘤中不表达NKG2D的患者相比，肿瘤中表达NKG2D的患者表现出显着更长的总生存期（OS）（P=0.0217）。在 ULBP1 和 NKG2D 阳性的患者中观察到最长的 OS，而在 ULBP1 和 NKG2D 阴性的患者中观察到最短的 OS。 ULBP1 和 NKG2D 之间的相互作用可能会改善胃癌患者的 OS，并可能在诱导癌症患者适应性免疫的免疫治疗中得到应用。此外，ULBP1 和 NKG2D 可能可用作胃癌的预后生物标志物。
UL16 binding protein 1 (ULBP1) expressed on the tumor cell surface binds to the natural killer group 2 member D (NKG2D) receptor presenting on natural killer (NK), cluster of differentiation (CD)8+ T, and γ δ T cells. However, the roles of ULBP1 and NKG2D expression and associated immune responses in gastric cancer are unclear. The present study investigated the associations between ULBP1 and NKG2D expression and clinical outcomes in patients with gastric cancer. The levels of ULBP1 and NKG2D expression were examined in human gastric cancer cell lines and gastric cancer tissues from 98 patients who underwent surgery from 2004 to 2008. MKN-74 cells expressed ULBP1 with ULBP2, −5, or −6. NKG2D was expressed at a higher level following activation of T cells and NK cells. Among the tissue sections positive for NKG2D expression, 6 patients were positive for CD8 and CD56. In all tissues, NKG2D-expressing cells were typically aCD8+ T cells. Patients with NKG2D expression in tumors exhibited significantly longer overall survival (OS) compared with patients without NKG2D expression in tumors (P=0.0217). The longest OS was observed in patients positive for ULBP1 and NKG2D, whereas the shortest OS was observed in patients negative for ULBP1 and NKG2D. The interaction between ULBP1 and NKG2D may improve OS in patients with gastric cancer, and may have applications in immunotherapy for the induction of adaptive immunity in patients with cancer. Additionally, ULBP1 and NKG2D may be useful as prognostic biomarkers in gastric cancer.
登录
查看更多内容
影响因子：
8
作者：
Zafirova, Biljana;Wensveen, Felix M.;Gulin, Maja;Polic, Bojan
通讯作者：
Polic, Bojan
影响因子：
6.4
作者：
Holdenrieder, S;Stieber, P;Salih, HR
通讯作者：
Salih, HR
影响因子：
56.9
作者：
Bauer, S;Groh, V;Spies, T
通讯作者：
Spies, T
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM
影响因子：
3.8
作者：
Loos M;Hedderich DM;Ottenhausen M;Giese NA;Laschinger M;Esposito I;Kleeff J;Friess H
通讯作者：
Friess H