Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer.
Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer.
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DOI：
10.1186/1471-2407-9-463
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发表时间：
2009-12-26
期刊：
影响因子：
3.8
通讯作者：
Friess H
中科院分区：
文献类型：
--
作者：
Loos M;Hedderich DM;Ottenhausen M;Giese NA;Laschinger M;Esposito I;Kleeff J;Friess H
共刺激信号已被认为是多种人类癌症抗肿瘤免疫的潜在调节因子。与胰腺癌细胞异常表达B7-H1的负面预后价值相反，B7-H3的作用仍然未知。因此，我们研究B7-H3在人胰腺癌中的表达规律及临床意义。采用免疫组化方法对68例行肿瘤切除术的胰腺癌患者的B7-H3表达进行了检测。表达数据与临床病理特征和肿瘤浸润T细胞数量相关。B7-H3在胰腺癌中的表达水平明显高于正常胰腺（p < 0.05）。68例肿瘤中有60例在胰腺癌细胞中检测到B7-H3蛋白。B7-H3高水平患者术后预后明显好于B7-H3低水平患者（p = 0.0067）。肿瘤B7-H3表达与肿瘤浸润性CD8+ T细胞数量显著相关（p = 0.018）。我们首次证实B7-H3在胰腺癌中大量表达，肿瘤相关的B7-H3表达与延长术后生存期显著相关。我们的研究结果提示B7-H3可能作为胰腺癌抗肿瘤免疫反应的潜在刺激物发挥重要作用。
Costimulatory signaling has been implicated as a potential regulator of antitumor immunity in various human cancers. In contrast to the negative prognostic value of aberrant B7-H1 expression by pancreatic cancer cells, the role of B7-H3 is still unknown. Therefore, we investigated the expression pattern and clinical significance of B7-H3 expression in human pancreatic cancer. B7-H3 expression was evaluated by immunohistochemistry in 68 patients with pancreatic cancer who underwent surgical tumor resection. Expression data was correlated with clinicopathologic features and with the number of tumor-infiltrating T cells. B7-H3 expression was significantly upregulated in pancreatic cancer compared to normal pancreas (p < 0.05). In 60 of 68 examined tumors B7-H3 protein was detectable in pancreatic cancer cells. Patients with high tumor B7-H3 levels had a significantly better postoperative prognosis than patients with low tumor B7-H3 levels (p = 0.0067). Furthermore, tumor B7-H3 expression significantly correlated with the number of tumor-infiltrating CD8+ T cells (p = 0.018). We demonstrate for the first time that B7-H3 is abundantly expressed in pancreatic cancer and that tumor-associated B7-H3 expression significantly correlates with prolonged postoperative survival. Our findings suggest that B7-H3 might play an important role as a potential stimulator of antitumor immune response in pancreatic cancer.
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