Zebrafish in Toxicology and Environmental Health.
Zebrafish in Toxicology and Environmental Health.
复制标题
DOI：
10.1016/bs.ctdb.2016.10.007
复制
发表时间：
2017
影响因子：
--
通讯作者：
Chu J
中科院分区：
文献类型：
--
作者：
Bambino K;Chu J
随着新合成化合物的生产工艺和开发不断增加，以跟上不断扩大的全球需求，环境健康和有毒物质暴露的影响正在成为关键的公共卫生问题。此外，环境中自然存在的化学物质，如金属，对人类和动物的健康有深远的影响。这些化合物中的许多都出现在新闻中：铅、砷和双酚A等内分泌干扰物近年来都被广泛宣传为对人类和野生动物造成疾病或损害。尽管人们普遍认识到环境毒素可能是有害的，但对有多少毒素导致疾病的了解有限。斑马鱼处于毒理学研究的前沿;该系统已被广泛用作检测水样中毒素和调查环境毒素及其相关疾病的作用机制的工具。斑马鱼对于研究脊椎动物发育的好处对于研究致畸剂同样有用。在这里，我们回顾了斑马鱼是如何被用来检测一些毒素的存在，以及确定环境暴露如何影响人类健康和疾病。我们专注于斑马鱼在生态毒理学和环境健康中最有效地使用的领域，包括对内分泌干扰物，工业废物副产品和砷暴露的调查。
As manufacturing processes and development of new synthetic compounds increase to keep pace with the expanding global demand, environmental health, and the effects of toxicant exposure are emerging as critical public health concerns. Additionally, chemicals that naturally occur in the environment, such as metals, have profound effects on human and animal health. Many of these compounds are in the news: lead, arsenic, and endocrine disruptors such as bisphenol A have all been widely publicized as causing disease or damage to humans and wildlife in recent years. Despite the widespread appreciation that environmental toxins can be harmful, there is limited understanding of how many toxins cause disease. Zebrafish are at the forefront of toxicology research; this system has been widely used as a tool to detect toxins in water samples and to investigate the mechanisms of action of environmental toxins and their related diseases. The benefits of zebrafish for studying vertebrate development are equally useful for studying teratogens. Here, we review how zebrafish are being used both to detect the presence of some toxins as well as to identify how environmental exposures affect human health and disease. We focus on areas where zebrafish have been most effectively used in ecotoxicology and in environmental health, including investigation of exposures to endocrine disruptors, industrial waste byproducts, and arsenic.
登录
查看更多内容
影响因子：
3.4
作者：
Evans, Sarah F.;Kobrosly, Roni W.;Barrett, Emily S.;Thurston, Sally W.;Calafat, Antonia M.;Weiss, Bernard;Stahlhut, Richard;Yolton, Kimberly;Swan, Shanna H.
通讯作者：
Swan, Shanna H.
斑马鱼中疾病的跨代遗传的二恶英诱导。
影响因子：
4.1
作者：
Baker TR;King-Heiden TC;Peterson RE;Heideman W
通讯作者：
Heideman W
影响因子：
1.5
作者：
Al-Eryani L;Wahlang B;Falkner KC;Guardiola JJ;Clair HB;Prough RA;Cave M
通讯作者：
Cave M
影响因子：
3.8
作者：
Antkiewicz, DS;Burns, CG;Heideman, W
通讯作者：
Heideman, W
影响因子：
3.8
作者：
Ball, Jonathan S.;Stedman, Donald B.;Augustine-Rauch, Karen A.
通讯作者：
Augustine-Rauch, Karen A.