Prenatal bisphenol A exposure and maternally reported behavior in boys and girls.
Prenatal bisphenol A exposure and maternally reported behavior in boys and girls.
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DOI：
10.1016/j.neuro.2014.10.003
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发表时间：
2014-12
期刊：
影响因子：
3.4
通讯作者：
Swan, Shanna H.
中科院分区：
文献类型：
--
作者：
Evans, Sarah F.;Kobrosly, Roni W.;Barrett, Emily S.;Thurston, Sally W.;Calafat, Antonia M.;Weiss, Bernard;Stahlhut, Richard;Yolton, Kimberly;Swan, Shanna H.
产前暴露于性腺激素在男性和女性大脑的正常发育和两性二态行为中起着重要作用。大脑结构和功能的激素依赖性差异表明，暴露于外源性内分泌干扰化学物质可能与性别特异性行为改变有关。双酚A （BPA）是一种环境化学物质，已被证明可以改变雌激素、雄激素和甲状腺激素的信号通路。流行病学和实验研究表明，产前暴露于双酚a和儿童行为之间存在关联，但数据不一致，很少有研究对学龄儿童进行调查。我们使用父母填写的儿童行为检查表（CBCL）检测了平均怀孕27周的妇女尿液样本中的BPA浓度与6-10岁儿童行为的关系。我们报告了153名儿童（77名男孩，76名女孩）的母体BPA尿浓度与几个CBCL评分之间的关系。我们观察到母性尿BPA与性别在一些行为（外化、攻击、焦虑障碍、对立/挑衅障碍和行为障碍特征）之间存在显著的相互作用，但BPA与任何CBCL量表的得分之间没有显著的关联。然而，在对产前尿液中检测到BPA的母亲所生的孩子（n=125）的分析中，BPA与男孩的内化和外化行为、孤僻/抑郁行为、躯体问题和对立/违抗性障碍特征的中度增加有关。此外，我们还观察到双酚a和性别在一些行为（外化、孤僻/抑郁、违反规则、对立/违抗性障碍特征和行为障碍特征）上的显著相互作用。这些结果表明，产前暴露于BPA可能与学龄男孩的行为问题增加有关，但与女孩无关。
Prenatal exposure to gonadal hormones plays a major role in the normal development of the male and female brain and sexually dimorphic behaviors. Hormone-dependent differences in brain structure and function suggest that exposure to exogenous endocrine disrupting chemicals may be associated with sex-specific alterations in behavior. Bisphenol A (BPA) is an environmental chemical that has been shown to alter estrogen, androgen, and thyroid hormone signaling pathways. Epidemiological and experimental studies suggest associations between prenatal exposure to BPA and child behavior, however data are inconsistent, and few studies have examined school age children. We examined BPA concentration in spot urine samples from women at mean 27 weeks of pregnancy in relation to child behavior assessed at age 6-10 years using the parent-completed Child Behavior Checklist (CBCL). We report associations between maternal BPA urinary concentrations and several CBCL scores in 153 children (77 boys, 76 girls). We observed a significant interaction between maternal urinary BPA and sex for several behaviors (externalizing, aggression, Anxiety Disorder, Oppositional/Defiant Disorder and Conduct Disorder traits), but no significant associations between BPA and scores on any CBCL scales. However in analyses restricted to children of mothers with detectable prenatal urinary BPA (n=125), BPA was associated with moderately increased internalizing and externalizing behaviors, withdrawn/depressed behavior, somatic problems, and Oppositional/Defiant Disorder traits in boys. In addition we observed a significant interaction between BPA and sex for several behaviors (externalizing, withdrawn/depressed, rule-breaking, Oppositional/Defiant Disorder traits, and Conduct Disorder traits). These results suggest that prenatal exposure to BPA may be related to increased behavior problems in school age boys, but not girls.
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影响因子：
10.4
作者：
Braun JM;Kalkbrenner AE;Just AC;Yolton K;Calafat AM;Sjödin A;Hauser R;Webster GM;Chen A;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
10.4
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
10.4
作者：
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通讯作者：
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影响因子：
6.1
作者：
Ehrlich, Shelley;Williams, Paige L.;Hauser, Russ
通讯作者：
Hauser, Russ
影响因子：
8
作者：
Duty, Susan M.;Mendonca, Kaitlin;Ringer, Steven
通讯作者：
Ringer, Steven