Biodegradable photo-crosslinked alginate nanofibre scaffolds with tuneable physical properties, cell adhesivity and growth factor release.
Biodegradable photo-crosslinked alginate nanofibre scaffolds with tuneable physical properties, cell adhesivity and growth factor release.
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DOI：
10.22203/ecm.v024a24
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发表时间：
2012-10-16
影响因子：
3.1
通讯作者：
Alsberg E
中科院分区：
文献类型：
--
作者：
Jeong SI;Jeon O;Krebs MD;Hill MC;Alsberg E
纳米纤维支架由于其高的表面积与体积比、互连的孔以及与天然细胞外基质的结构相似性而在组织工程中受到关注。我们的实验室最近开发了一种可生物降解，可光交联的藻酸盐生物聚合物。在这里，我们展示了该材料被电纺成纳米纤维基质的能力，以及通过用细胞粘附肽共价修饰来增强这些基质上的细胞粘附和增殖的能力。此外，证明了在光聚合过程中将肝素共价结合到水凝胶中以通过亲和相互作用维持肝素结合生长因子的释放的潜力。电纺光交联藻酸盐纳米纤维支架赋予细胞粘附配体和生长因子的受控递送可以允许改善再生医学的细胞行为的调节。
Nanofibrous scaffolds are of interest in tissue engineering due to their high surface area to volume ratio, interconnected pores, and architectural similarity to the native extracellular matrix. Our laboratory recently developed a biodegradable, photo-crosslinkable alginate biopolymer. Here, we show the capacity of the material to be electrospun into a nanofibrous matrix, and the ability to enhance cell adhesion and proliferation on these matrices by covalent modification with cell adhesion peptides. Additionally, the potential of covalently incorporating heparin into the hydrogels during the photopolymerisation process to sustain the release of a heparin binding growth factor via affinity interactions was demonstrated. Electrospun photo-crosslinkable alginate nanofibrous scaffolds endowed with cell adhesion ligands and controlled delivery of growth factors may allow for improved regulation of cell behaviour for regenerative medicine.
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影响因子：
14
作者：
Nillesen, Suzan T. M.;Geutjes, Paul J.;van Kuppevelt, Toin H.
通讯作者：
van Kuppevelt, Toin H.
影响因子：
14
作者：
Freeman, Inbar;Kedem, Alon;Cohen, Smadar
通讯作者：
Cohen, Smadar
影响因子：
14
作者：
Ji, Y;Ghosh, K;Rafailovich, MH
通讯作者：
Rafailovich, MH
影响因子：
3.6
作者：
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通讯作者：
Kim, Young Ha
影响因子：
9.7
作者：
Park, Kyung Min;Lee, Sang Young;Park, Ki Dong
通讯作者：
Park, Ki Dong