Trends in incidence and survival outcome of epithelial ovarian cancer: 30-year national population-based registry in Taiwan.
Trends in incidence and survival outcome of epithelial ovarian cancer: 30-year national population-based registry in Taiwan.
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DOI：
10.3802/jgo.2013.24.4.342
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发表时间：
2013-10
影响因子：
3.9
通讯作者：
Lai MS
中科院分区：
文献类型：
--
作者：
Chiang YC;Chen CA;Chiang CJ;Hsu TH;Lin MC;You SL;Cheng WF;Lai MS
[目的]探讨台湾地区上皮性卵巢癌30年来发病率及预后的变化。从台湾国家癌症登记系统检索1979-2008年间上皮性卵巢癌妇女的资料。分析这些患者的发病率和预后。共有9491名患者参加了这项研究。1979~2008年每5年上皮性卵巢癌的年龄调整发病率分别为1.01、1.37、2.37、3.24、4.18和6.33/10万人年。年龄别发病率上升，尤其是浆液性癌、子宫内膜样癌和透明细胞癌，确诊年龄在30年内从60岁下降到50岁。粘液性癌、子宫内膜样癌或透明细胞癌患者的长期存活率高于浆液性癌患者(LOG RANK检验，p<；0.001)。未分化癌或癌肉瘤患者的生存率比浆液性癌患者差(对数等级检验，p<；0.001)。确诊时年龄在30-39岁的死亡风险显著高于年龄在70岁以上的患者(趋势检验，p<；0.001)。与1991年至1995年期间相比，从1996年至1999年期间(危险比[HR]，0.9；p=0.054)至2000年之后期间(HR，0.74；p<；0.001)，死亡风险有所下降。上皮性卵巢癌患者的发病率在增加，确诊年龄在下降。组织学类型、诊断年龄、疗程是影响卵巢上皮癌预后的重要因素。
To investigate the changes of incidence and prognosis of epithelial ovarian cancer in thirty years in Taiwan. The databases of women with epithelial ovarian cancer during the period from 1979 to 2008 were retrieved from the National Cancer Registration System of Taiwan. The incidence and prognosis of these patients were analyzed. Totally 9,491 patients were included in the study. The age-adjusted incidences of epithelial ovarian cancer were 1.01, 1.37, 2.37, 3.24, 4.18, and 6.33 per 100,000 person-years, respectively, in every 5-year period from 1979 to 2008. The age-specific incidence rates increased especially in serous, endometrioid and clear cell carcinoma, and the age of diagnosis decreased from sixty to fifty years old in the three decades. Patients with mucinous, endometrioid, or clear cell carcinoma had better long-term survival than patients with serous carcinoma (log rank test, p<0.001). Patients with undifferentiated carcinoma or carcinosarcoma had poorer survival than those with serous carcinoma (log rank test, p<0.001). The mortality risk of age at diagnosis of 30-39 was significantly higher than that of age of 70 years or more (test for trend, p<0.001). The mortality risk decreased from the period of 1996-1999 (hazard ratio [HR], 0.90; p=0.054) to the period after 2000 (HR, 0.74; p<0.001) as compared with that from the period of 1991-1995. An increasing incidence and decreasing age of diagnosis in epithelial ovarian cancer patients were noted. Histological type, age of diagnosis, and treatment period were important prognostic factors for epithelial ovarian carcinoma.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
DOI：
10.1097/pas.0b013e3181cf3d79
发表时间：
2010-03
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Kurman RJ;Shih IeM
通讯作者：
Shih IeM
DOI：
10.1067/s0002-9378(03)00579-9
发表时间：
2003-10-01
影响因子：
9.8
作者：
Barnholtz-Sloan, JS;Schwartz, AG;Munkarah, AR
通讯作者：
Munkarah, AR
影响因子：
168.9
作者：
Beral, V.;Doll, R.;Risch, H. A.
通讯作者：
Risch, H. A.
影响因子：
45.3
作者：
Chan, John K.;Sherman, Alexander E.;Deshmukh, Harshal
通讯作者：
Deshmukh, Harshal